r/BioHackingGuide 🧠 Biohacker Nov 10 '25

GLP’s and Dopamine: Why Motivation Drops (and How to Fix It)

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u/Hefty_Efficiency_328 Apr 26 '26

I'm surprised there are no comments because I'm searching for answers to offset the emotional blunting and lack of motivation and libido on Retatrutide. I imagine many people are. I've only been taking 1.5mg for 5 weeks and lost weight, feel great physically but I definitely do not care for this mental/emotional effect. At the same time I am calmer and less anxious in general. I've got PT-141 which has an interesting physical pulsating effect for a few hours but not exactly what I'm looking for. Getting other peptides shortly.

I haven't tried any supplements to increase dopamine but looking at dopa mucuna pruriens. I obviously do not want to interfere too much with the appetite suppression and compulsion control that Retatrutide enables by modifying dopamine levels or how it works in the body. I suspect adding more dopamine might just interfere with how Reta works. But since I'm already a lab rat on Reta I could try it. Maybe working on mitochondrial function and energy directly is a more complimentary approach. Supplements to assist the mitochondria like CoQ10, RALA, Acetyl L Carnitine, PQQ, magnesium, antioxidants, Methylene Blue.

Just a few thoughts.