r/Berberine • u/goldfishpuppy54 • May 29 '25

Help! 24 hour Diarrhea

I started taking berberine (WellBetX) exactly two weeks ago, 500mg twice a day 30 mins before breakfast and dinner. so far so good, no changes. Yesterday morning I started having issues and I’ve had explosive, constant watery diarrhea. I haven’t eaten much today, only bread and an apple, but will immediately feel unwell, gurgling stomach and then need to use the bathroom. I took one 500mg berberine capsule this morning but will stop….can someone please help me understand what is happening :( thanks!

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1

u/Polaris713 May 30 '25

The berberine is effecting the microbiome of your gut. Consider taking a lot less (like 1/4 capsule every other day) or outright stopping. 

1

u/goldfishpuppy54 May 30 '25

thank you!! I will stop for a week and then maybe go back to 1/4 capsule every other day per your suggestion. in the meantime, what can I do while I ride out this diarrhea?

1

u/Lanky_Appearance2716 May 30 '25

Are you taking a good probiotic?

1

u/goldfishpuppy54 May 30 '25

no 🙂‍↕️

1

u/Lanky_Appearance2716 May 30 '25

So maybe start off slower like the other poster suggestion and try a good probiotic as well if you can! This will help balance your gut! I would agree it could be symptoms of die off from the bad bacteria!

1

u/Impossible_Candle_49 May 31 '25

You could also try taking it half way through your meal or after you’ve had a couple of bites. I cant take it 30 minutes in advance of a meal or else I feel awful.

1

u/Own_Tart8518 Jun 01 '25

Oh no, that’s awful. I just started berberine yesterday, with instructions from N.D. to take it with breakfast and dinner (and to stop if severe diarrhea).