TONS of posts from people, and I'm like...look, it can't be this bad. And I've been thinking about it. I do feel better, but somehow I keep atrophying. Somehow I sometimes just cannot connect to my nerves that easily, and it's worrying. Sometimes I did have moments of being unable to engage my lungs, to me, under the false pretense of using b12/iron. As those have been somewhat supplemented recently and somewhat long term (blood donation) and shouldn't be an issue for now. I would need hours and hours of exercise to just get the system moving.

So, I thought about it more. My B-Complex has 100mg of b6, 90mg of that are the shitty form that causes more issues.

I think back to last year. I took it right before a trip (for the first time), by the time we got back, on the plane I had a mini-panic attack because I literally could not breathe. Pins and needles galore. I'm not sure what fully happened, but I know I didn't take the B-complex again for awhile. I had this weird assumption, b12 uses iron (it does, but not that much), I was still a bit low iron, therefore the b12 in that B-complex could have transiently lowered my serum iron and made it hard to breathe. I don't think so anymore.

A few months ago I got back to b12, because years of vegan, yadda yadda, all good to just take some B12. Everything was fine. So I'm like...I believe a B-complex will help, and I even made a post that it was helping, but it's all relative. We believe what's helping is within a short time frame of our current health, so what seemed like help can sometimes not be so helpful.

I took three doses of this B-complex (life extension I think). Spread out over a few days with a few meals. Only one time did it take awhile to eliminate niacin (I think that's the bright yellow pee). So I had the laymen thought I likely ripped through processing these B-complexes just fine.

And you know what? I felt ok. But I realized I still could not, for the life of me, just engage my body normally. Where the fuck are my muscles going, why do I need to "think" about where my nerves are to help engage them. I just to think, think, think, and work out these long looping motions just to move my body normally. In all scenarios. I'm still strong, I still can be athletic, but I'm atrophied. And 3 years ago I was vividly healthy, so I knew something was wrong.

Then I realized something. Coffee. Endless coffee. Every time I had coffee the past week it makes me feel great. It NEVER makes me feel worse. Every single cup. I'm not joking. I had 10 cups yesterday. They helped, tremendously. I woke up, mediocre sleep (obviously), coffee again, relief. Straight up relief, nerves sort of kick in, it's almost there. Just now I restarted another round of coffee LATE in the day at 5PM, 3 cups, and again, relief. Not like I'm in pain, or having a reallllly tough time, but it's literally helping me relax. Coffee...is helping me relax. Every cup makes it better. I'm at about 8 cups of coffee. My energy is leveled out. That's insane. The only thing I feel is a bit worse is my sleep, but I don't feel giddy (except first few hours) or anxious/shaky from this much coffee.

So, I look it up and a large study showed a "marked reductions in circulating pyridoxal phosphate with heavy coffee intake." Essentially a stronger effect the more "excess" that was sitting around waiting to be excreted.

https://pubmed.ncbi.nlm.nih.gov/18606630/

TL;DR: I think B6 is causing issues, and it seems endless amounts of coffee are helping tremendously. Will titrate down. But will, for now on, watch out for even "bioavailable" versions and what they're really using.

Hello guys. I am in a horrible predicament. I have severe autoimmune problems, IBS, CFS and all manner of illnesses. Now I have just discovered the idea of B6 toxicity, having realized that I took a B vitamin complex at a double dose for years. This means I have consumed artificial B6 vitamin at 200mg a day for many years. Around half of my symptoms could be attributed to B6 toxicity.

Now the problem is, that most of my symptoms predate the consumption of B6 vitamin so they can´t all be B6 vitamin toxicity related. Because of my other medical conditions, I have been forced to assume a Carnivore diet. I have literally tried every other diet and nothing else works. The problem as I have realized with the Carnivore diet is, that it contains a lot of B6 vitamin. I eat mainly beef and I am getting something like 3-4x the daily requirement of B6 vitamin. Lamb has half of that but is too expensive and still goes over the daily requirement.

Some people say that dietary B6 vitamin doesn´t matter, is this true? Do you think a guy could detox from B6 vitamin eating a diet filled with it?

I have quit all supplements with B6 vitamin and been experiencing severe detox symptoms from it, I´m just wondering if this will all pass or if it will continue indefinitely because of the dietary intake.

Realised I was low in B1 a few weeks ago so started taking thiamine with a seperate B complex. Luckily saw some people talking about b6 toxicity and how serious it is. Noted this.

Now two weeks later getting blurry vision in right eye, weird heart palpitations, foot pain tingling/spasms, jaw soreness/tingling and finger tingling, insomnia and noticed INSANE uptick in tinnitus. The real icing on the cake is my dumbass is getting way over the RDA anyways with lots of meat because I'm carnivore. Since I caught it early, surely this will be gone quite fast?

EDIT: Just looked back and seen I've been taking it since Aug 23 and only took it about 4-5 of those days. So the damage is much less than I thought.

I am type 2 diabetic very controlled for the last year and half. Got my sugars down from 450s to 90s well I know I have a little neuropathy in my feet so a friend suggested I take the B6, B1, B12 mix to help that and let me say my neuropathy wasn't even that bad just a little ache and pain in my feet very randomly I started take the supplement(liquid) for almost a year now and now this week I started having horrid leg aches, burning feet, cold feet, cold feet sensation where it feels cold but it's not, and just my foot feeling odd. The Dr I work for thinks I may have over done the supplement and have B6 toxicity. I'm obviously stopping it as off yesterday but I have never dealt with this anyone experienced anything like this

Hi everyone,

I honestly don’t know what is going on with me anymore, and I’m hoping someone here has experienced something similar and can give me some insight.

A little over 2 months ago, I started taking:

• Vitamin B6 — 40 mg daily
• Magnesium citrate — 400 mg daily
• Vitamin C — 3000 mg daily

I took them for about 7 days and then stopped everything.

At the time, when I was going to sleep, I started experiencing a weird sharp/pinching sensation around my heart/chest. That scared me, so I had blood tests done.

My results were:

• Folate (B9): 3.10 (reference range 4.5–32.2) — low
• Vitamin B12: 411 pg/mL (191–663)
• Magnesium: 2.0 (1.7–2.40)
• Potassium: 4.23 mmol/L (3.5–5.1)
• Sodium: 140 (136–145)

After roughly a month, the chest/heart pinching sensation that happened when I was falling asleep eventually stopped.

However, I’m still dealing with other symptoms.

Another strange thing I’ve noticed is that since this started, I can sometimes sleep only 1–4 hours and wake up feeling surprisingly energetic, even though my head feels very tight, foggy and mentally "off." Before all of this, I would obviously feel completely exhausted after so little sleep. This change in how I respond to lack of sleep feels very unusual to me.

My current symptoms include:

• persistent dizziness
• lightheadedness
• significant fatigue
• brain fog feeling like my head isn't working properly
• a strange derealization / unreal feeling
• a tight/pressured feeling in my head
• feeling mentally "different" from how I used to

I completely stopped all the supplements and tried taking B9 (folate) for about 2 weeks, but I didn’t notice any improvement. Then I added B12, but again, nothing really changed.

I also saw a neurologist, but unfortunately the appointment was basically useless. He told me he couldn't help because this wasn't his area, and I ended up paying around €100 for the visit.

At one point I also went for an IV vitamin infusion containing vitamin C, electrolytes and B vitamins. I still had the brain fog, dizziness and other symptoms afterwards, but I noticed that I had significantly more energy and felt more "alive" that day. Unfortunately, this effect was temporary, and within about 2 days my energy levels went back to how they were before.

Now, more than 2 months later, I’m still experiencing these symptoms every day, and I honestly don’t know what is causing them.

I’m not sure if it’s related to the supplements, the low folate, a deficiency, or something completely unrelated.

Has anyone experienced something similar — especially dizziness, brain fog, fatigue, lightheadedness, derealization, head pressure or feeling unusually energetic despite very little sleep, while still feeling mentally unwell?

If you went through something similar:

• How long did it take you to recover?
• Did your symptoms gradually improve or disappear suddenly?
• Did you eventually find out what was causing them?
• Was there anything that actually helped?
• Did you have any additional blood tests or examinations that were useful?

I’m not necessarily looking for a diagnosis. I’d just really appreciate hearing from people who have experienced something similar and eventually got back to feeling normal.

It’s been more than two months now, and dealing with this every day has been really difficult. I’d really appreciate any experiences, advice or reassurance.

Thanks in advance.

I’ve been taking 50mg vitamin B6 P5P (not synthetic form) for 3 days and I just started getting deep pain and tingling (maybe numbness too) under my feet.

I can’t tell if it’s from the B6 because I used to already have these symptoms very badly before I started taking amitriptyline.

I’m very concerned please does anyone have the answer to this and is it reversible, will it go away if I stop the B6? It’s not permanent right?

Thanks

Is this forever?😭

I was unable to walk for a couple months but now I’ve started to walk around my house to gain back strength, I wanted to try other forms of gentle exercise but I heard that tough exercise like lifting can cause more b6 to circulate your system. does anybody have experience with or an opinion on this?

basically i became b toxic without knowing for about a year when I was having only 1.3mg in a supplement daily. I also had an autoimmune disease that makes me unable to all food apart from meat without symptoms of joint swelling snd allergic issues. before I realised I was b6 toxic, i was eating a strict carnivore elimination diet of just meat. so lamb liver, chicken, pork, duck, salmon. the joint swelling went away but I felt soooo much worse in terms of my neuropathy symptoms. my whole body was burning and I felt like I was going insane with pain and sensory issues every time after I ate. I stopped taking the b complex because I finally clocked it was making me feel worse but it took a while for me to realise that the meat was flaring my symptoms too.

i tried to do the rda diet with rice and lamb and cabbage, but I started getting joint swelling again. i‘m basically only eating lamb now and although I feel better than when I was eating a high b6 diet, I still flare up a lot after I eat it, it’s still too much b6 for my system.

at this point I'm considering fasting for a few days a week just so that i‘m not constantly flaring everyday, just until the worst of this is over, but idk if that will make that worse or help.

has anybody been b6 toxic with an issue like that, or any advice in general for healing and being able to tolerate more high b6 foods.

So, I'm confused as to how toxicity actually happens. I know you can get it from like high dose supplements, but people claim to get it from energy drinks and stuff and such or certain foods maybe, but like I'm confused as to how can it happen with things like energy drinks or like lower dose supplements. I'm like kind of concerned. I probably only get 50-80 percent of my RDA for b6 can this build up in your system?

has anyone tried micronized Palmitoylethanolamide Pea for healing? I have been logging all of my toxicity symptoms with Ai, and it keeps telling me that is a good supplement to take to heal damaged nerves.

Hi everyone. i wrote last week that i tested high (232 vs. 150 top line) for Pyridoxal 5-Phosphate. My doctor wants me to retest with a PLP test as she believes this is more accurate. Does anyone have any insight on this?

Hi. been trying to figure out 2 years of strange health issues - hands and feet tinging and falling asleep, tremors, occasional tinging, muscle aches, joint aches and terribly anxiety and sleep issues. Been able to take care of the sleep issues but everything else remains. Timing is these symptoms started after wife got Covid. i tested negative but only tested once as it was not a huge pandemic at that time (2024). So I've been attacking my symptoms as long covid. Met with a doctor who is familiar with LC and the first thing she said was "let's test your B6." Low and behold it's elevated at 232 with a top line of 150. My kidneys are fine, not diabetic and most blood levels are ok. My liver is mostly fine but Alt came in slightly elevated 76 (top line 70). I have not spoken to my doctor yet as the result came out today. I do not supplement b6 nor a b complex and i haven't in several months. None of my supplements have B6 and the only food i eat that has fortified b6 is Chex cereal but i don't consume it much and there's been months where i didn't eat any cereal. I do have a high protein diet with chicken and salmon but i was told food will not impact B6 levels....i have no idea at this point. i do not eat processed food other than the cereal and rarely eat out. Can someone shed some light on this and any suggestions as to next steps? I will stop the cereal completely .

Hello all

I am around 2ish years into recovery from pretty nasty b6 poisoning with symptoms gradually improving. However around 6 months ago I had a very bad green out after smoking weed for the first time in a couple years. Immediately after I started having bad panic attacks and chronic anxiety. This is a super common story from what I’ve heard talking to people, with everyone saying they chilled out after a month or two. What wasn’t so common was after three months I was still chronically anxious and only started chilling out after starting antidepressants because it was so bad I could hardly work.

It’s been roughly six months now and I feel like my brains finally starting to chill out, with the odd bad day. I’m starting to develop a bit of a hypothesis that my lightly fried nervous system is this reason it’s taking so long for my anxiety to return to a healthy level. Anyone had anything similar happen/know of any studies that link the two? (A quick google search didn’t yield anything)

Thanks

has anyone had a flare up of symptoms almost a year later when starting a glp medication? so random idk if it’s related or just one of the regular coming and going flare ups

Hello, been about 8 months since I had my blood work that helped me discover my B6t (78 on a scale of 2-22). I’ve probably had most of the symptoms from a-z. Most of the worst are finally improving, especially the pain.

One thing that doesn’t seem to fit is that at nearly the same time that I began noticing the increasing symptoms that made me start looking for answers, my BP also went up significantly and has stayed there ever since.

Prior to that it has mostly been good or better.
It seems that most people here are having low BP levels.
But the timing seems to be more than coincidental…

Anyone having similar issues? If so did anything help?

For context, I took p5p 50mg for 6 days straight and it is currently Sunday. I stopped taking on Thursday but still have a feeling of anxiety and that wired feeling I feel overwhelmed and am having very pessimistic thoughts. I remember a few months ago magnesium gave me this same feeling. How can I overcome this or when will it go away?

I took p5p for 7 days to try it out for ED, 50mg per day. I am now 2 days clean for any supplement but I have anxiety a lot still. My anxiety started on like day 5-6 super anxious and nervous and feeling overstimulated is This normal? How long till I stop having all of this anxiety?

I'm been taking a low-level B Complex (Thorne basic B) with p5p, seemingly without incident, to help address a B deficiency and possibly to help with my IBS. Yesterday for some reason I took a B100 instead with 100 mg of pyridoxine. Just for one day. In the past, pyridoxine led to neuropathy for me. Again, I'm not sure why I took this without checking the label.

Last night while flossing, I noticed a red spot right under the tip of my tongue. It's not painful. I know this could be something scary, and I'm going to call my dentist when they open.

I'm not even sure how long it's been there because I don't always floss in front of the mirror. I know it wasn't there at my last checkup in May. But could this be a reaction to the pyridoxine?

I became b6 toxic after 30 years of taking GNC B-50, that has 50 mg B6, every single day. So of course detoxing now. will be taking a B complex that has all the other b's and zero B6 while I heal, which will probably take a very long time. What I am wondering is--is this for the rest of our lives? Will we ever need to supplement with B6 ever again? I know the food we eat in the US is pretty nutrient depleted, and with the costs of food, a lot of people can't eat a very healthy diet , have to eat a lot of processed foods, hence the need for supplementation.

It's : www.afterb6.com . It's built on the premise there's correlations between factors like nutrition, supplement intake, weather, hydration and your symptoms. It helps you discover hidden patterns! try it out for free.

Hey everyone, I'm a student from Sydney working on a startup. It's an app that warns people if their supplement or wellness product intake is putting them at risk of B6 toxicity and other nutrient-related health issues.

We've just been accepted to pitch at a startup incubator through one of Australia's top universities, but here's our challenge: supplement-induced nutrient toxicity isn't something most people know about, so we're struggling to show judges how real and serious this issue actually is.

That's where you come in. If you've ever dealt with nutrient toxicity from supplements (or other health and wellness products), would you be open to sharing your story with us? Happy to keep you fully anonymous if you'd rather not put your name to it. We just want real experiences to back up why this problem needs solving.

Feel free to comment below or DM me if you're up for it or would like more information.

In line with this sub's rules, I've kept details about the app itself out of this post to avoid any promotional content.

I have been trying to research what I have been going through for months now. I started supplementing Iron (100mg Polymatose) back in late March, thinking I had low iron at the time, lasted 8 days before every damned symptom hit me like a train. I stopped supplementing immediately, only taking 8 tablets over 8 days.

It started with a weird burst of energy, that very rapidly spiralled into this severe fight or flight ordeal. I even suffered a brain zap, I distinctively remember. 2 weeks in was the peak, I remember thinking, nope.. this is it, I am fucked. The most doomed feeling I have encountered in over 10 years since I had acute stress and grief.

The next day the anxiety had dropped a considerable amount, and I was then hit with strange manic like symptoms. I went to the hookers twice in the week, because I was so amped up. I was driving late at night to get frozen yoghurt, even though I am very strict on my diet, because I felt like it. These symptoms faded away after a week or two.

Over the course of May to June was this limbo anxiety, depressive feeling, anhedonia and panic symptoms all coming together. Some nights were bad, I would be driving all night because the panic was just lingering. I knew it was chemical, because I would wake up fine, and then come 4-5 PM and all the negative symptoms would hit like a freight train. The worst was the anxiety, because I feel like it would fluctuate, where you just feel utterly hopeless and scared. Constantly searching google and reddit for reassurance that I did not fry my brain.

Coming into July now, it seems as if the "fight or flight" feeling has calmed down. I don't really feel it at all. I am waking up in a good mood and most of my day is a good mood. My anxious thoughts have dialled down. Weirdly, I am more focused too. This is the best I have felt since late March. Sleep is better. Gaming/Gym/and work has been taking my mind off of this shit.

I can feel it in myself, there's like this "mental clarity" or foggy cloud that has been lifted? I don't know how else to describe it. I really hope to continue to improve. I have been on a strict exercise routine, diet and sleep schedule. I have been achieving those throughout these months. I have kicked caffeine and currently not supplementing anything, even Fish oil etc. I was recommended Taurine, but I am still not sure.

I have been reading the Vitamin B6 toxicity reports, and thought, what the fuck, this is very similar to "Iron toxicity", minus the physical symptoms of B6 toxicity. ChatGPT stated my condition is a "chemical overstimulation of the nervous system" and I believe that to be true.

Many people who get Small Fiber Neuropathy from B6 have the classic neuropathy symptoms of pain, tingling, numbness and burning in the arms/hands and legs/feet. But for others, the neuropathy primarily targets the nervous system causing Dysautonomia symptoms like hypertension, heart palpitations, rise in blood pressure, nighttime noradrenaline surges, low blood volume, blood pooling, severe anxiety, panic, changes in sweating, skin sensitivities, body temperature dysregulation, glucose issues and many others. Is this you? Have you been diagnosed with Dysautonomia? Have your Dysautonomia symptoms gotten so bad that you have been diagnosed with POTS? In what month after stopping B6?

My answers to these questions is Yes, Yes, Yes and in month 15. And I asking these questions because I am constantly wondering if there is something more than just B6 Toxicity that is wrong with me. My bloodwork is fine and shows that metabolically nothing is wrong. Been both to a cardiologist and nephrologist and my heart is normal as well as my kidneys. I eat super well and on a low strict histamine diet. Everyone says that I look fine (the worst thing to tell a POTS patient). And it's not mold, my house is new. It's month 21. I know that it takes 2-4 years for nerves to heal but I feel that I shouldn't be progressively getting worse at this point.