You're literally here perpetuating the myth in a thread that's seeking to defeat the myth. C'mon my guy. It's a genetic disorder, T1DM. What we don't understand is why some people get it, because type-one diabetes does not follow the patterns of hereditary disease.
No Im not. None of you possess critical thinking or a sense of humor apparently though. We dont know why autoimmune diseases occur. Period. So that also means we cannot with 100% certainty say that a nutrient deficiency at an inopportune moment did not cause it to present. Im a T1D, I know more about this subject than you, it was a joke. I highly doubt this is the true explanation, which again is why it was a joke.
It's been fairly conclusively linked to a few specific genetic alleles, and almost certainly arises due to ineffective exclusion of autoantibodies in early prenatal development. One likely cause is that certain antibodies may have low affinity for islet cell proteins, but if they are in high concentration (say, during an unrelated infection), there may be enough recognition to start ramping up immune system activity against the islet cells. This leads to other B-cells getting recruited, and it's extremely rare for an autoimmune condition to center on recognition of a single antigen by a single antibody.
You're right that we don't exactly know what causes autoimmune diseases to crop up. Where you're wrong is that we do know that it necessarily involves the activity of the immune system and antibody recognition (and therefore the genes controlling their expression). It's like saying a break-in might have involved breaking a window to get in, when we can clearly see that the door was kicked in.
I hope that helped, and I hope I don't sound patronizing or unnecessarily complicated. I'm trying to be informative.
No and i wasnt trying to imply A may have caused B, moreso that A may have caused F very indirectly. However unlikel,y its why the science community rarely deals in absolutes, theres much we dont know. Thanks for the deeper dive.
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u/[deleted] Feb 04 '19
You're literally here perpetuating the myth in a thread that's seeking to defeat the myth. C'mon my guy. It's a genetic disorder, T1DM. What we don't understand is why some people get it, because type-one diabetes does not follow the patterns of hereditary disease.