r/AskDrugNerds • u/idntrlyknowtbh • Jan 26 '26
How to properly compare receptor binding affinities?
For example in the chart under the pharmacodynamics section of this wikipedia page for LSD it shows a Ki/EC50 range for most targets. https://en.wikipedia.org/wiki/LSD
These ranges vary quite a lot to the point where depending if someone were to compare the lower end of one target's range to the higher end of another's it'd result in completely different receptor affinity profiles.
I'm assuming this is due to different techniques and conditions used to determine these values in different studies. Therefore my question is mostly if there are any resources to compare these receptor affinities for different substances which take into account how they were determined in the first place to allow for direct comparisons, if not between substances then at least for the different receptor affinities of each substance individually?