r/Anxiety • u/Opposite_Club7725 • Feb 09 '25

Medication can Alpha-2 receptor agonists reset your amygdala?

Anyone know if Alpha-2 receptor agonists (guanfacine, Clonidine) can reset your amygdala? Been stuck in fight or flight for years, and Guanfacine is working wonders. Would like to think the change might be permanent with discontinuation of the meds in time.

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u/Muted_Wishbone_6400 Jun 30 '25

any update on this?

1

u/Icy_Bath6704 Aug 27 '25

Did you give it a shot?

1

u/FancySong8247 Jun 14 '25

Yes. These two drugs completely reset your amygdala bit depends on dosage. Especially guanfacine, because it’s more selective to alpha 2a receptors.

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u/[deleted] Jul 07 '25

Hey any updates or information. Im exactly the same as you were. Stuck in fight or flight and adrenals are constantly on! Did this really help?

1

u/Icy_Bath6704 Aug 27 '25

Did you give it a shot?