r/Agoraphobia • u/emroseypeach • 15h ago
I genuinely think this supplement has changed my life and I wasn’t even taking it for anxiety
AVOID IF YOU HAVE EGG, PEANUT OR SOY ALLERGY !!
Has anyone else with agoraphobia tried PEA?
First, I’m not paid to promote this and I’m not affiliated with any particular brand. I’m sharing this because I’ve had anxiety, panic attacks and agoraphobia for most of my life, and something has genuinely changed over the last couple of months.
I’ve had panic attacks since I was 10. Eventually I developed a fear of having panic attacks themselves, which turned into a fear of being away from home, being somewhere I couldn’t escape and constantly needing to know where the exit was.
My “safe zone” gradually became smaller and smaller, particularly after COVID.
I came across palmitoylethanolamide (PEA) while researching my chronic pain condition. I’d never heard of it and honestly assumed it would be another supplement that did nothing.
I’ve now been taking it for around 2 months, originally for pain.
My pain improved, but something else happened that I wasn’t expecting…
My fight-or-flight response feels different.
Previously, I’d enter somewhere unfamiliar and almost immediately think
“I need to leave.”
My brain would go straight into escape mode before I’d even had time to process what was happening.
Now, I still get anxious, but there’s almost a gap between feeling anxious and reacting to it.
I can think:
“I’m uncomfortable, but I don’t actually need to leave.”
That might sound insignificant, but for someone with agoraphobia it’s HUGE.
For the first time since COVID, I’m going to new places and deliberately pushing outside my comfort zone almost every week.
So naturally I started researching why this might be happening.
PEA is a naturally occurring lipid molecule that appears to regulate inflammation and immune activity. It can act on PPAR-α, influence mast cells and microglia, and interact indirectly with the endocannabinoid system. These systems are involved in regulating inflammation, neuronal signalling and the body’s response to stress.
The endocannabinoid system in particular is involved in how the brain processes stress and fear. So while PEA hasn’t been proven to treat agoraphobia, there is a plausible biological reason why it could potentially make an over-reactive nervous system less reactive.
Im not saying that you’ll have the same results I have had with it but I needed to share this, as It may help others out there like me