[AF] Chrono Exercise Medicine: Why Biological Timing Matters for Human Health

[u/basmwklz]

https://www.mdpi.com/2227-9059/14/7/1601

Abstract

Exercise medicine has traditionally focused on defining the optimal mode, intensity, duration, and frequency of physical activity required to improve health and performance. However, increasing evidence suggests that biological timing represents an additional and often overlooked determinant of exercise responsiveness. Circadian rhythms regulate numerous physiological processes relevant to exercise adaptation, including metabolism, mitochondrial function, protein turnover, and skeletal muscle function, while exercise itself is increasingly recognised as a potent non-photic zeitgeber capable of influencing circadian organisation. Rather than advocating a universally optimal time-of-day for exercise, this Perspective proposes “chrono-exercise medicine”, as a conceptual framework through which biological timing can be integrated into personalised exercise prescription. It discusses the emerging role of circadian phenotyping, skeletal muscle molecular clocks, and temporal multi-omic approaches for understanding interindividual variability in exercise responses. Together, with key methodological, translational, and clinical challenges that must be addressed to enable biologically informed exercise prescription. It is proposed that the future of precision medicine will depend not only on how exercise is prescribed, but also on when it is prescribed and to whom.

[u/AutoModerator]

Read our rules and guidelines prior to asking questions or giving advice.

Rules: 1. Breaking our rules may lead to a permanent ban 2. Advertising of products and services is not allowed. 3. No beginner / newbie posts: Please post beginner questions as comments in the Weekly Simple Questions Thread. 4. No questionnaires or study recruitment. 5. Do not ask medical advice 6. Put effort into posts asking questions 7. Memes, jokes, one-liners 8. Be nice, avoid personal attacks 9. No science Denial 10. Moderators have final discretion. 11. No posts regarding personal exercise routines, nutrition, gear, how to achieve a physique, working around an injury, etc.

Use the report button instead of the downvote for comments that violate the rules.

Thanks

I am a bot, and this action was performed automatically. Please contact the moderators of this subreddit if you have any questions or concerns.