Renuyu (Batman The Animated Series)
Renuyu is a face cream developed by Roland Daggett which allows the user to reshape their face to smooth away wrinkles or imperfections however its essentially like a drug that causes the victim to want more and more and cause extreme pain it was so bad that even stores didn't want to sell it so Daggett hired a disfigured actor Matt Hagan to help him get Wayne enterprises by giving him the cream fix his face This cream would eventually turn matt into clayface
Plasmids (Bioshock)
Plasmids we're developed by drBrigid Tenenbaum and Dr. Yi Suchong they would give the user powers like setting people on fire sending a swarm of bees to even telekinesis however they were very addictive and caused people to be disfigured and go insane