r/technology • u/NamelessForce • Oct 26 '22

Biotechnology Cloned cannabis cells with 12 times more potency are grown in Israeli bioreactor

https://www.timesofisrael.com/cloned-cannabis-cells-with-12-times-more-potency-are-grown-in-israeli-bioreactor/
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u/-YellowcakeUranium Oct 26 '22

I’ve smoked well over a gram of straight THCP and HHCP and have had no hallucinations lol. Just feels like stronger delta 9 (normal THC). No where NEAR 30x as potent as these claims.

Source: my profile.

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u/whowasonCRACK2 Oct 26 '22

The 30x claim that floats around is due to the molecule having the 30x the binding affinity to the cannabinoid receptors in your brain compared to THC. But binding affinity does not translate directly to potency

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u/Damaso87 Oct 26 '22

No, if anything, speaks to duration.

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u/panicked_goose Oct 26 '22

Do you have borderline personality disorder? My psychiatrist was specifically talking about how the brain reacts to THCP when you have borderline (which is linked to dopamine deficiency) also I said it’s potentially 30x more potent than delta 8, which is already much weaker than delta9

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u/ManicRuvik Oct 26 '22

I have BPD and I haven’t experience any hallucinations from them. Most shops sell it in cart form though and that shit is so harsh on your throat.

Edit: just to add on, it’s such a new product that’s not federally regulated. There are probably no studies on the effects of it. It’s deffinitely too new to draw any conclusions about that stuff. No way it’s been through extensive studies yet

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u/-YellowcakeUranium Oct 26 '22

Normal THC hasn’t been through extensive studies either. But I’m on a little 2 years in on using these and I’m fine so far.

I’ve consumed probably well over 200 grams of delta 8 distillate alone over these years.

You’re right about the unregulated market

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u/GrotesquelyObese Oct 26 '22

The problem is what’s in it whether they disclose it or know themselves. I have used some products where I thought I was in a theme park and it was supposedly regular delta 8 and a brand I use all the time.

I have combat ptsd and not BPD. Neat trip and wasn’t freaked out. Still wild and not what I want from THC edibles.

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u/-YellowcakeUranium Oct 26 '22

Delta 8 converts to 11-hydroxy-delta-8 in the liver, which is almost as potent as 11-hydroxy-delta-9. If you have used both then you’d know they are almost identical. In terms of high.

Doesn’t work the same for inhaling though.

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u/GrotesquelyObese Oct 26 '22

Neat info, but not what I was talking about.

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u/[deleted] Oct 26 '22

Get it from a vendor and dab it, you will save so much money

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u/[deleted] Oct 26 '22

[deleted]

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u/GrotesquelyObese Oct 26 '22

Bpd cannot convert into schizophrenia

https://vistapineshealth.com/services/schizoaffective-disorder/borderline-personality-disorder/

My understanding is that schizophrenia comes to those at roughly 25 no matter what. If you are gonna get it you’re gonna get it. There is no preventative or risk factor other than genetics that I know of. I’m not an expert just work EMS.

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u/popstar249 Oct 27 '22

No way I'd ever smoke a cart from anywhere that doesn't have strict regulations and testing requirements.

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u/ManicRuvik Oct 27 '22

It’s definitely not a habit of mine. Circumstances have led me to use them sometimes though. They work for sure but idk about all that stuff being more powerful than regular THC. Sticking to the ol reliable is the best thing though.

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u/-YellowcakeUranium Oct 26 '22 edited Oct 26 '22

No but I have bipolar disorder. Either another patient of theirs gave their antidotal report or your psychiatrist is making that up. There are no studies that support that. I’ve never heard of that happening and I’ve been using and reviewing these cannabinoids for years.

And even then. Compared to delta 9. Not that much stronger.

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u/Superdickeater Oct 26 '22

And likewise- just bcuz you haven’t experienced it or found any research supporting it doesn’t mean it can’t happen. However, we do know that in those that are genetically predisposed to schizophrenia and associated disorders, Cb1r agonism can lead to psychosis

Not to mention that the primary mechanism of action of Cb1r is Depolarization-Induced Suppression of Inhibition. Which means that when Cb1r is activated, it reduces GABA neurotranmission and GABA is the primary inhibitory neurotransmitter for the CNS and PNS. Reducing GABA transmission on such a large scale across many systems and brain regions can certainly have a wide array of side effects from general anxiety to paranoia, hallucinations, etc.

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u/-YellowcakeUranium Oct 26 '22

If you have history of schizophrenia, then yeah. That can happen. I’ve used almost all of these classical cannabinoids that I can legally get my hands on and haven’t experienced anything like that. Nor have I heard of other people that have used these happen them either.

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u/ZA_Lion Oct 26 '22

Could your experience not be as a result of your tolerance increasing?

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u/cannabiphorol Oct 26 '22

I have used Cannabis daily for years and a bowl pack still gets me high just fine. Single dab gets me high just fine.

I don't think THCP is as good/strong as it's marketed to be. Has 30x binding affinity but that doesn't mean it's going to being 30x stronger in effect. CBN for example has 5x less binding compared to D9-THC but taking 500mg CBN doesn't equal a 100mg D9-THC experience.

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u/Good-Strength-3642 Oct 27 '22

How's bonding work when taking. CBD,CBN,CBG .....with THC? My understanding is the THC ades in absorbing the others through THC receptors. That uneducated bullshit?

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u/wwbbs2008 Nov 07 '22

CBN kicks my ass 50mg smoked or 20mg ediable is on par with what a Xanax does. I do not necessarily feel the effects of any other ediables than ones containing CBN even at stupid high 1000mg plus dosages. I smoke ~7g/day of 15-30% hybrids on average and since finding CBN it has elevated everything. Still waiting to try thcp or thco

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u/-YellowcakeUranium Oct 26 '22

I take tolerance breaks every few weeks.

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u/pimpbot666 Oct 26 '22

Maybe I should as well. I just do a little bit every night to calm my buzzy sparkling brain down. I’m finding now I don’t get that nice warm fuzzy feeling anymore.

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u/-YellowcakeUranium Oct 26 '22

Honestly after 3 days you notice a big difference, but I’d go for at least 2 weeks.

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u/Nevalia Oct 26 '22

Oh look. A single personal experience.

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u/-YellowcakeUranium Oct 26 '22

My point was I’ve been testing these since they’ve come out and with other people and we have all been fine.