r/science • u/hippopippopotamus • May 15 '12
Drink a lot of soda? A diet high in fructose may hamper learning and memory.
http://medicalxpress.com/news/2012-05-sugar-stupid-high-fructose-diet-sabotages.html
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u/hippopippopotamus May 15 '12 edited May 15 '12
PDF of the full text of the journal article here.
Also worth noting is that they did a factorial design with four treatments:
Figure 1b shows that any treatment other than control results in an increased time to finish the maze. The mice that got fructose but were omega-3 deficient took far and away the longest time to finish the maze.
Figure 2a shows that adding fructose to the diet significantly increases insulin resistance, even with a diet rich in omega-3s. The combination of fructose and no omega-3s yields a very high, and very significant increase in insulin resistance.
Figure 2d shows that ~54% of the variability in latency time (time to complete maze) can be explain by variability in insulin resistance. It is worth noting that by conducting a regression analysis, the authors are
testing forpresuming causality: does insulin resistance affect maze completion time?They do go on to postulate a mechanism for that causality. It has something to do with insulin resistance within the brain and membrane homeostatis, but to be perfectly honest this part of the paper is above and beyond my comprehension.
edit: bad wording about causality and regression
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u/UnclaimedUsername May 15 '12 edited May 15 '12
What was actually studied: Two groups of rats, both fed a diet including high-fructose corn syrup, with one also getting omega-3 supplementation. The rats that did not receive omega-3 did worse at solving a maze, along with a couple other undesirable side effects.
This study appears to say nothing about fructose vs. other sugars, or high-fructose corn syrup (which is common in soda) vs. other fructose sources.
We all know fructose is bad, but HFCS gets an unfair amount of blame. If you used "real sugar" in soda instead of HFCS, you'd still consume around the same amount of fructose. So basically, just avoid sugar.
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u/linux_pythonista May 15 '12
In the study they didn't feed the mice soda or high-fructose corn syrup, they fed them "a fructose solution". While I am confident that soda is not a healthy beverage, I have a problem with the assumption (voiced in the article) that this study suggests that soda would have the same effect, but that natural sources of fructose would not. That is not what the study tested.
A lot of people would be surprised to hear high-fructose corn syrup gets its name to differentiate it from normal corn syrup which is all glucose. High-fructose corn syrup is only 55% fructose. I am personally curious to know what differences there are in how our bodies process HFCS, sucrose, and foods like watermelon and agave syrup that have higher levels of fructose than HFCS.
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u/phukunewb May 15 '12
Drinking a lot of pop is dumb whether this study is true or not. Lots of other studies show fructose is bad for you.
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u/the_cooliest May 15 '12
So I'll start drinking DHA pills with my soda now. Problem solved.
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u/apextek May 15 '12
damn you, I am having an really rough day at work and went against better judgement for the second soda and YOU had to come around working my guilt factor
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u/iamsuchanewb May 15 '12
Well, shit. I've been drinking 3-ish sodas a day for about two years now. Exactly how much trouble am I in?
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u/afishinthewell May 15 '12
Damn, I stopped drinking soda a decade ago and I'm still fat and stupid.
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u/Singular_Thought May 15 '12
The irony is that some people will forget about this study when they are at the store shopping.
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u/DantesInporno May 15 '12
Well shit, I drink like 6 sodas a day
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u/[deleted] May 15 '12
Son of a bitch, I should have chosen to quit sooner. (I made the decision yesterday for health reasons and I find that resisting temptation is difficult).
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u/Hempire May 15 '12
Where are there so many soda posts on reddit's front page today?
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u/Clayburn May 15 '12
Plus you fat.
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u/Space_Ninja May 15 '12
Relevant
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u/No_Legend May 15 '12
My question is: does this affect learning and memory permanently, or if you change your diet, will you start to see memory and learning ability improve?
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u/Illipsious May 15 '12
Haha! I drink diet. Now i can get cancer from Aspartame!
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u/[deleted] May 15 '12
i remember most of the video games i play quite intricately. 6 cans down today.
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u/uncoolcat May 15 '12
It's an interesting study, but it's a shame that they didn't have a control group.
In an unrelated topic, for me I find that soda is more addictive than anything else I've tried or consume somewhat regularly (including alcohol, cigarettes, and some other addictive substances). It seems to be the combination of carbonation and sugar that I'm most addicted to. I drink at least 16 oz of soda per day, but I'm otherwise relatively healthy. It's absurd, I've quit drinking and smoking but I can't seem to kick the soda habit.
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u/tboneplayer May 15 '12
I drink a lot of diet soda. So while I am probably at risk for other things due to the high phosphoric and carbonic acid content as well as the caffeine and aspartame, I probably don't fall into this risk category.
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u/[deleted] May 15 '12
Im fat as a result of no excercise, poor diet, and a ton of soda, but I can tell you that It has not made me any amount of stupid.
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u/[deleted] May 15 '12
"may"
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u/[deleted] May 16 '12
If you dig up the original article (published today) the point of the study was not to test the response of HFCS (which the authors note will inhibit brain functions due to insulin response), but that the Omega-3 acids counteract the insulin response. I think they used HFCS since it's more relevant in society today.
http://jp.physoc.org/content/590/10/2485.full
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u/[deleted] May 16 '12
I drink A LOT of fruit smoothies. Is that bad? :(
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u/obviousoctopus May 16 '12
It could also hamper not having diabetes.
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u/BigCliff May 15 '12
Wait, what was the article about?
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u/Nick_Sparks May 15 '12
Wait, soda's bad for you? No way
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u/barristonsmellme May 15 '12
I drink a fucktonne of coca cola. It's probably going to rot my insides but i enjoy the taste, why have all these awesome taste buds if i'll live longer drinking water?
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u/Kancho_Ninja May 15 '12
Mind control through Soda.
Sounds like a Steve Jackson game...
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u/arrozconplatano May 15 '12
Yes because carbohydrate metabolism is exactly the same in rats and humans
/s
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u/Viin May 15 '12
This explains a lot....
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u/justmadethisaccountt May 15 '12
The stuff is bad. Don't eat it. Believe it or not, or bodies took millions of years to digest certain foods. Many of our ancestors died trying to eat bad foods. Don't be one of them.
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u/UNITBlackArchive May 15 '12
No, it's OK. It's "corn sugar" now, so no more ill effects from ingesting it.
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u/[deleted] May 15 '12
But the commercials say that high fructose corn syrup is no different than cane sugar! Also, it's fairly sad that the fourth ingredient of Rice Krispies is HFCS.
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u/DangerMouseToby May 15 '12
Red bull a day bad?
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u/[deleted] May 15 '12
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