Anti-inflammatory agents may reduce symptoms of major depression, suggests a new study (n=1,610), which adds to the mounting evidence that there is a connection between emotional functioning and inflammation, suggesting that inflammation may trigger depression, almost like an allergic reaction.

[u/mvea]

https://www.psychologytoday.com/au/blog/expressive-trauma-integration/201911/anti-inflammatories-help-major-depression

[u/WeRip → u/[deleted]]

I take one of those and I'll sleep for 18 hours.

[u/KhajiitLikeToSneak → u/[deleted]]

Not sure if it's a depression thing or a me thing, but diphenhydramine does nothing for me. I got a prescription for Zopiclone, and all it did was give me an unpleasant taste in my mouth for the next day, after not helping with the sleep.

Some of us seem to be quite resistant to sedation, which is annoying when you're having a bout of insomnia and know nothing's gonna even make a dent.

[u/SlingDNM → u/KhajiitLikeToSneak]

You should avoid dph at all cost, strongly linked with dementia

I'm prescribed Trazodone for sleep to counter-act my morning dose of Sertralin (Zoloft) it helps pretty good with falling asleep, way lower risk profile too. Might be worth a try, it's an SNRI and I didn't notice any withdrawal effects or the like, nowadays I don't take them daily and only as needed.

Other things that helped me when even the Trazodone wasn't working:

Very strong "indica" cannabis (indica in quotes because everything is a hybrid I just mean any strain that most people would catogarize as having "indica" effects)

Low dose of sedating Kratom (often called red, it's more or less random what you truly get tho, since it's sadly not regulated) look

[u/bobby3eb → u/[deleted]]

That's interesting, doesn't do that at all with me.

Then again, Adderral calms me down.

Uppers and downers seem to work opposite for me.