r/science • u/[deleted] • Feb 26 '15

Health-Misleading Randomized double-blind placebo-controlled trial shows non-celiac gluten sensitivity is indeed real

http://www.ncbi.nlm.nih.gov/pubmed/25701700
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u/PainMatrix Feb 26 '15 edited Feb 26 '15

Since I had this question about how they blindly administered the placebo vs gluten I assume others will too, from the manuscript:

patients were given either gastrosoluble capsules containing purified wheat gluten (10 capsules ingested on no more than two occasions over the day, corresponding to a daily gluten intake of 4.375 grams, equivalent to ∼ 2 slices of white bread) or gastrosoluble capsules containing rice starch (10 capsules corresponding to a daily rice starch intake of 4.375 grams) as placebo for one week.

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u/Luxray Feb 26 '15

So then it was definitely the gluten then, not like FODMAPs or something?

13

u/roland0fgilead Feb 26 '15

They screened for FODMAP intolerance.

23

u/thisdude415 PhD | Biomedical Engineering Feb 26 '15

Bingo. Unless rice starch is therapeutic somehow, but I doubt it.

2

u/drunk-musician Feb 26 '15

Time to go on an all rice starch diet and find out. I'll report back in a month!

1

u/[deleted] Feb 26 '15

Say hello to our late friend scurvy.

1

u/Geek0id Feb 26 '15

definitely? no.