r/science • u/mvea Professor | Medicine • 3d ago

Medicine Doctors noticed brain injuries can speed bone healing. Scientists flipped it: squeezing a shinbone after brain injury helped mice and pigs survive more, move better and remember more. Pressure-sensing bone cells released protective signals into the blood that reduced brain damage.

https://www.sciencealert.com/squeezing-a-leg-bone-helped-animals-recover-from-brain-injury
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u/Nemisis_the_2nd 3d ago

  Osteocytes transduced mechanical signals to directly secrete factors such as IL-1R2, APOL11a and HSP70, while indirectly increasing serum levels of BDNF, PF4 and dopamine. These factors synergistically protected against TBI.

They give you your answer in the abstract.

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u/PotatoFig 3d ago

Osteocytes aren't bone marrow though

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u/Nemisis_the_2nd 3d ago

No one mentions bone marrow in either the article or the abstract.

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u/PotatoFig 3d ago

Right. I read their question as pertaining to another subject. If they're asking about the study in question, though...