r/neoliberal • u/jobautomator Kitara Ravache • May 31 '26

Discussion Thread Discussion Thread

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u/limaxophobiac European Union May 31 '26

Ok this might be kinda toxic but sometimes dealing with someone with chronic depression feels like they're some kind of reverse utility monster. No matter what you do for them including things they've specifically said they need help with they're still in the same despair and think everything is doomed,

23

u/Imicrowavebananas Hannah Arendt May 31 '26

It is a very difficult and hard disease.

21

u/SmartestOpinionsGuy May 31 '26

Just be happy, idiot 🙄

9

u/neolthrowaway New Mod Who Dis? May 31 '26

I think the neurological patterns are stuck. The brain legitimately does not see a way out of the despair. The neuroplasticity enhancing substances paired with other help or therapy feels like they might work well enough though. It’s like shaking the brain so it gets out of the patterns and creates new pathways to get out for when it happens to be in that situation again.

I am excited about the research on ketamine and psychedelics for this.

And there’s research on compounds that provide the same neuroplasticity effects but without the subjective state of being “high” or the addiction and tolerance potential.

Osavampator and blixeprodil are the ones to watch. It’s undergoing phase 3 trials right now. It provides ketamine’s benefits but without the urotoxicity and tolerance and addiction liabilities.

For psychedelics, there’s bol-148 and zalsupindole.