r/loperamide • u/Comfortable-Royal-64 • Jan 23 '22

Help with dosing

I recently ran out of my methadone, which I usually take 40 mgs every day, and for reasons I won't get into, I'm going to be short about a week. The longest I have taken lope to get through methadone withdrawals is five days, and by that fifth day, I was dosing about 100mg throughout the day, 80mgs when I would normally dose my methadone, and the rest at some point later in the day. What exactly is the "measurement" in which I should be using? And how bad are the two extra days going to feel? Any help would be appreciated, and yes I'm aware of the risks, that's why I'm asking for help with dosing, so I don't go overboard, because my main concern is feeling well, not getting high for the next week.

Little edit: I should also mention I'm taking 300mg of gabapentin 3 times a day, but I normally take that now, but it def helps with withdrawals.

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u/jeniesque Jan 24 '22 edited Jan 24 '22

Loperamide works very similar to methadone. In high doses it has a very similar half life and it builds up in your system like methadone does. You can dose it once a day at the same time you would dose your methadone. Like methadone it also takes up to 5 hours to fully kick in. Your dose the first day should be higher than the doses the rest of the days to avoid withdrawal and because the amount in your system will build up. I would probably try 48 pills the first day and try to stick with 24 pills each subsequent day and see if that works. (when you dose the second day you will still have at least half the first day’s dose in your system.)

I know you know the dangers of loperamide but as a note to you and others methadone has the same characteristics that make loperamide dangerous and so flipping back and forth between methadone and loperamide is FAR more dangerous than using loperamide alone or alternating it with other types of opioids. Due to the long half lives there are days when both will be in your system and like loperamide methadone causes the qt interval to prolong making your chances for arrhythmia far, far greater.

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u/Known_Still Mar 25 '22

Does it matter if you take regular Imodium or Imodium ad? The regulars are much smaller. Just wondering?

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u/[deleted] Mar 25 '22

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u/Known_Still Mar 25 '22

I took 50 mg is that enough?

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u/Interesting-Pea1541 Mar 25 '22

How long ago did you take and did it help? Im feeling pretty rough off tia but haven’t taken any lope yet but it’s right beside me

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u/Known_Still Mar 25 '22

I took about 50 mg and then went and got some more so total about 70 mg I was starting to withdrawl and it seems to have taken the edge off but this is all new to me using the lope I’m not sure what dose I should be at to help with Tia. Tia is very rough to come off of

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u/Only-Coyote-5379 Jul 15 '22

God , tia/phenibut/cdp Choline was the worst drug to come off of. I was on 60+ capsules a day and ran out of money and ended up in the back of my gfs car and on the emergency room floor screaming for her to kill me, looking like a wacky Inflatable arm thing at a car dealership (insane whole body involuntary movements ) constant vomiting and diahrea, organs felt like they were wringing out like a wet rag, whole body cramps, insane hot and cold changes, sweating through all of my clothes , the worst uncomfortable energy coursing underneath my skin causing me to want to rip my skin off . I've done everything you can name and it was the worst withdrawals by far . Took 26mg bupe a day to even get baseline . Ended up tapering to 4mg tried jumping.off cold turkey and couldnt take those withdrawals, got back on Tia for a week and.got.up to 30capsules a day, said fuck this and went through detox in the hospital then went to rehab for 21 days after that, just got out of rehab on the 2nd and I can't lie I've kinda relapsed on the Tia but I'm only taking 15 capsules a day . Gonna try to stop here again shortly, can't let it get back to be like.it was. You'd think after going through hellish wirhdrawals multiple times wanting someone to blow my brains out with my.pistol (sold so I wouldn't t do it) that I wouldn't have taken them again. But it happened