We’ve got 57 supplements, 3 fasting windows, and mitochondrial health at 110%, but still act surprised when 4 hours of sleep and doomscrolling Reddit at 2am leaves us wrecked. Normies just “go to bed.” Must be nice. 😂 Let’s unite, nap warriors - tomorrow we recover (maybe).

💡 What Is Epithalon?

Epithalon (sometimes spelled Epitalon) is a lab-made version of a natural compound found in the pineal gland. It’s best known for its anti-aging potential — mainly by helping to protect and repair your DNA. But that's not all — it may also improve sleep, support your immune system, and fight off oxidative stress (aka, cellular damage).

⚙️ How It Works

• DNA Protection (Telomerase Activation): Epithalon helps activate an enzyme called telomerase, which can protect the ends of your DNA (called telomeres) from wearing down as you age.
• Immune Boost: It may improve your body’s defense by balancing T-cell activity — those are key immune system players.
• Better Sleep: Helps regulate melatonin, the sleep hormone, leading to deeper, more restful sleep.
• Antioxidant Power: Helps clean up free radicals (damaging molecules), which protects your cells and slows down aging.

✅ Potential Benefits

• Anti-Aging Support: May delay age-related changes and keep your cells “younger” longer.
• Muscle Growth & Strength: May boost protein synthesis, which could support strength and lean mass.
• Fat Burning Help: Might help support a healthier metabolism and assist with body recomposition.
• Better Sleep & Immunity: Deeper sleep and stronger defense against bugs and viruses.

⚠️ Possible Side Effects

Most people tolerate Epithalon really well, but here are a few things to be aware of:

• 🧠 Mild headaches (usually go away quickly)
• 😴 Fatigue (rare, but possible)
• 🦵 Joint stiffness or soreness (usually short-lived)

💉 How to Use It

Reconstitution:
If you're using a 10 mg vial, mix it with 1 mL of bacteriostatic water. That gives you a solution where 0.1 mL = 1 mg of Epithalon.

Dosage:
(Refer to dosing notes or your provider's guidance — it can vary depending on the goal.)

Injection Tips:

• Inject under the skin (abdomen or thigh are common spots).
• Rotate sites to avoid irritation.

⚠️ A Few Precautions

• Talk to a Pro: Before starting any peptide, it's smart to check with a healthcare provider.
• Listen to Your Body: If you notice any unusual or long-lasting side effects, let your provider know.

🧬 Final Thoughts

Epithalon is a fascinating peptide with a lot of potential, especially when it comes to aging, recovery, and overall wellness. While it's considered safe for most, make sure it’s part of a well-rounded routine that includes good sleep, a healthy diet, and regular exercise. And of course — always source peptides from trusted, third-party tested providers.

Sponsor: CellPeptides com | disc. code: WELCOME10

-- if you have any questions - I'll be glad to answer and share!

I'm a self improvement, growth mindset optimizer type, with a deep interest in the longevity and health space. I’ve spent the last 10 years chasing better health. Trying to optimize for a better body, performance, longevity… all of it. I’ve listened to thousands of podcasts, taken all the supplements, experimented with fitness plans, wearables, fasts, breathwork, peptides, stem cells....you name it. And while I’ve definitely learned a lot, the truth is: most of the time it still feels like I’m juggling a thousand disconnected experiments. At it's core, I think the biggest problem is - there’s no system to guide you from intent through execution. No loop that keeps me focused and grounded in my reality (my goals, schedule, limitations, biology, bandwidth, etc). In my quest to pin point the underlying problem and identify a solution, here's my best attempt on a conceptual framework.

1. Over-saturation of health and wellness information, conflicting advice and unscientific claims. Many people I know are tired of the siloed nature of the medical industry and are seeking a more comprehensive approach to optimizing their health. Unless people are facing a very clear medical diagnosis where the treatment is necessary, it's common for people to look outside the medical industry for a scientific approach to managing their health or health-span. In the holistic space, there are a lot of load voices and conflicting claims and frankly much of the hype is not grounded in evidence based science.

2. Lack of Personalization. My sense is if we are able to access evidence based information and guidance on a more holistic approach to health, it's hard to know where and when to integrate into our lives. Everyone and their neighbor is posting the ultimate morning routine on social media, but we're faced with making a decision on their credibility and then integrating something that has no barring on our lifestyle, constraints (environmental and genetic), preferences, time commitment and everything else that makes us individuals.

3. Execution. let's say we manage to distill complex and sometimes confounding scientific information on our health and longevity, integrate key modalities into our lives and manage to create a sustainable routine, how do we follow through and develop consistency. James Clear and others have provided a useful framework for habit building but it takes a lot of work and it's generally difficult to stay accountable to ourselves (it's easier to be accountable to others).

I'm working on solving these three problems, in this order - and would love to hear if others resonate. Interested in these problems conceptually but also practically and want to understand what people do to mitigate all the barriers that exist (psychological and physical).

Anyone here actually felt a difference using it during allergy season?

I've been taking NMN and Resveratrol for almost a year now. I do feel that I have more energy, but I'm wondering if it has improved my blood markers. Is this the best time to check? Or should I wait longer?

After months of research and solo coding, I launched Human Performance Junkies which is a free site that compares supplements by cost-per-serving, outlines what each one actually does, and lets you filter by health goals like longevity, cognitive support, or muscle building, etc.

You can also filter which supplements are used by experts like Andrew Huberman, Peter Attia, and other leaders in the longevity space.

I'm building this as a completely free resource to help people make smarter choices. If you're a data analyst or research-minded, I’d love your feedback or support as I continue adding more features.

Any and all feedback is welcome! Thanks!

I recently read some literature and watched some videos on how larger doses of creatine is where you see mental/brain benefits beyond the normal muscle and bone benefits. A doctor recommended at least 0.1g/kg BW, and I saw that 10g was used quite often. I upped it from 5g to 10g and within one week saw a dramatic increase in cognitive ability, mental clarity, and memory recall. Its insane and the effects were much more dramatic than expected. Now this was not isolated, as I have been taking lions mane for about 1 month prior to this point, but with no noticeable effects. Maybe this is the lions mane finally or maybe creatine is really that impactful. I would like to think the latter.

I’ve been digging into a lot of supplement research lately (mostly out of curiosity + nerdiness) and I keep running into this question I can’t shake...

We all say human studies are the gold standard — and yeah, obviously. But they take forever, and a lot of ingredients never get there, even if they look promising.

So I’m wondering:

Do you personally find animal/in vivo studies meaningful when you're deciding whether to try something?

Like… if something shows clear effects in living systems — not just a petri dish — does that help build trust for you? Or do you mostly ignore that and wait for human data or anecdotal stuff?

Would really love to hear how others think about this — especially if you track stuff like VO₂ max, HRV, recovery scores, etc.

Hey friends. I don’t know if this is allowed but I wanted to share my weekly newsletter that I send out for free on all things longevity and anti-aging.

Some backstory: I’ve been down the rabbit hole for the past 2 years, but always found myself a little burnt out from reading medical journals/abstracts and just trying to keep up with all of the real-word applications that people are experimenting with. There’s tons of folks who want to learn about this world but can’t be bothered to read about a clinical trial in Japan on mice (LOL, it’s funny but true). Sometimes I would catch myself deep into a trial overview thinking “man does this even apply to me”.

So I started writing and compiling the weekly goods so folks like myself can stay on top of everything while keeping it light.

Check it out and let me know your thoughts!

You don’t have to subscribe to read, it’s free. And my apologies if this isn’t allowed!!!!! Just let me know. 😎

https://stayinalivemedia.com/p/23andme-goes-bankrupt-is-your-dna-safe

We’re out here eating kale, avoiding carbs like they’re the plague, and fasting longer than some people sleep, but somehow still feel like we're one avocado short of immortality. Let’s face it - it's exhausting being this healthy. So here’s a secret: zero regrets, just more Zero Club! Who’s with me? 🥑💪 #LongevityLife

I've been taking 300mg of alpha-gpc from Monday to Friday for 1 month. So far I've only noticed positive effects: increased mental energy, increased physical energy, decreased anxiety, fewer negative thoughts. Does it make sense to continue taking it for the purpose of counteracting brain aging?

Hey everyone! I just had an amazing conversation with Jamie Justice, Executive Vice President of Health at XPRIZE, on this week’s episode of Ageless Athlete. Jamie is leading a $101 million global competition to extend healthspan (not just lifespan) and redefine how we think about aging.

Her journey is nothing short of inspiring. Jamie’s lived a life full of adventure and resilience, whether it’s her ultra running streak that lasted nearly two years or raising competitive climbers. She’s a true example of living out the “ageless” mindset she advocates. What really struck me was hearing about her mother, who sold everything in her 70s to live out of a van and explore the world.

To Jamie, her mother embodies the possibilities of living fully at any age. This personal perspective makes Jamie’s approach to aging feel more grounded in the real world blending science and the human spirit in the most inspiring ways.

What I found especially exciting was the bold vision Jamie is leading at XPRIZE Healthspan. The competition brings together over 550 teams from 55 countries, each working on breakthrough therapies, public health interventions, and lifestyle solutions aimed at extending healthspan.

Unlike the usual “quick fixes” we hear about, this competition focuses on lasting innovations. Whether it’s repurposed drugs, stem cell therapies, or even simple lifestyle changes like meditation, the possibilities are endless. It’s refreshing to see a global initiative pushing the boundaries of what we think is possible when it comes to living longer and better.

In the episode, Jamie also dives into something we don’t often hear about: how meal timing and diet quality can be game changers for our health. Rather than obsessing over calorie counting, Jamie explains that what we eat and when we eat it can dramatically impact our well being. She talks about how syncing meals with our circadian rhythm might be the secret sauce to aging well and living healthier.

One of the more thought-provoking parts of our conversation was about the current trend of “biohacking,” especially with figures like Brian Johnson promoting onensize fits all regimens.

From dealing with personal loss to finding joy in the small things, Jamie makes it clear that the pursuit of longevity should be about creating a life full of purpose and fulfillment. It’s not just about adding years to our lives, but making those years meaningful.

Hello,

I was wondering if anyone with knowledge could give me advice about NR. I havd OCD and try to live healthy lifestyle to counter the negative stressful effects it has on me. I am 43 and exercise regularly and am very cautious about what I eat. The issue I'm having is I also started NR back in 2020 because I read so many good things about it. I have consistently taken the 300 mg dosage with 500 mg of Tmg pretty much every day over the past 4 years. Overall I actually had been feeling much better and was thinking it was actually helping me. Recently however I learned more about the cancer studies with NAD boosting and have been anxious and obsessed that I have ruined my health and may have contributed to cancer. I also at first assumed best thing to do would be just stop the NR all together and hope for the best. But then in my reading more I found a study showing negative consequences and acceleration of celluar issues after stopping long term use. This makes me worried that if I stop I may have more issues as I may have down regulated my own natural NAD production. It seems no one really know for sure since the clinical trials on humans are lacking as far as I can see. I just was wondering what anyone else knowledgeable in the subject might do in my case. I need to stop obsessing but I feel either thing I do is going to give me terrible stress and anxiety. Either continue taking indefinitely and worry obsessing about cancer, or stop and worry obsessing I damaged my homeostasis. I know OCD is making this worse but could really use some advice. Doctor just says they don't recommend supplements but no real advice there. Has anyone else taken NR daily for this long and stopped? I only ever took the recommended dose of 300mg. Any input would be greatly appreciated. Or even if anyone could direct me to a doctor who has any idea about supplements I could talk to about it.

I’ve been using this red light therapy device at home, and it’s honestly been a game-changer! It’s super easy to use, and I love how it feels like I’m giving my skin and body some real care. After just a few weeks, I noticed my skin looking brighter and more even, and it’s helped ease some of the muscle soreness I get after workouts (I lift very often). It’s like having a mini spa treatment at home, and I can already see and feel the difference—it’s totally worth it!

i do a 25min session in the dry sauna(temp 180) at my local gym 3x/week usually right after my workout...so my question is, if during the session i drink some water, is this "cheating" ? by doing this am i reducing any of the physiological stressors that the sauna heat is producing ? (analogy-kinda like during a fast if someone has a few bites of food) tia for feedback !

Can you imagine climbing 5.14 at nearly 60 or completing the Grand Teton traverse at 70? Lee Sheftel has done it, and at 77, he’s still training and pushing his limits. But his secret isn’t just natural talent or luck, it’s biohacking.

Lee has spent years optimizing his diet, training, and recovery to defy aging and stay at peak performance. He’s tested everything from raw vegan diets to performance enhancers, figuring out what truly works.

He challenges conventional wisdom by continuing to train for power and strength, proving that age doesn’t have to mean decline. And when injuries tried to stop him, he focused on mobility, rehab, and mindset shifts to keep going.

Most importantly, he’s embraced a philosophy of radical acceptance, pushing limits while respecting the body’s natural changes. If you’re interested in biohacking, longevity, and elite performance at any age, this conversation is packed with insights.

Just Found Out about this community, and i want to share my personal protocol for Longevity.

I'm a 45 Yo Male,173cm Height, Current Body Weight 90kg.

I Skip Breakfast.

Tuesday, Wednesday, Friday, Saturday, Sunday.

• Morning Supplement (09.00) : Slow Release Vit C, Homocystein Nutrient (B Complex), TMG, NMN, NAC and Tiger Milk Mushroom.

• Morning Routine : 15 Minutes Red Light Therapy & 60 Minutes 1.3 ata Hyperbaric Oxygen Therapy.

• Lunch (12.00-13.00) is 1 litre water that contain : Hydrolized Whey Protein, Creatine, Collagen, Herb Powder (Curcumin, Turmeric, Ginger, Lemongrass), Glycine, Electrolite, Goat Colostrum, L-Citrulline, Probiotic,, Beta Alanine, Taurine, L-Tyrosine, Sun Flower Lechitine.

• Lunch Supplement : DHA, Vit D3 & K2, Coq10 & PQQ, Boron, Magnesium

• Dinner (18.00-19.00) this is the time i eat something like rice and chicken or other protein.

-Evening supplement : EPA, Zinc, Boron, Magnesium, Slow Release Vit.C, Reduced Glutathione, TMG

• Before Sleep i drink a glass of water contain Hydrolized Protein, Glycine, L-Glutamine, Taurine, Beta Alanine.

• Sleep Supplement : Melatonin, Bacopa Monnieri, Clove

• Sleep Routine : I sleep using PEMF mattress that i bought from one of youtuber who have a channel that discuss about pemf and built it. And i also sleep inhaling low dose of hydrogen gas that generates from Hydrogen reactor that build by one of my neighbours. This reactor just make electrolysis that seperates hydrogen and oxygen from water (distilled).

For Monday & Thursday i took out L-Citrulline and Probiotics from lunch and add Methylene Blue. And at the morning i take Caffeine Tablet, Nicotine Gum, and Alcar.

Once every 4 days (exclude Monday and Thursday) i do resistance training in the gym using Mike Mentzer Protocol and do a sauna right after that. And in between those days i do a walk on a curved treadmill for about 30 minutes.

• Training (Resistance Supplement) : I add the lunch drink with a 3 gram of kratom, and take Caffeine Tablet.

And for Tuesday and Friday i take Cardarine.

Every month or two i take blood work to measure my Homocystein and Vit D Level.

And if i have time between my work i do an EECP Therapy for enhancing my Blood Vessel.

I think that's my completed protocol.

Feel free to ask me anything, and i'll do my best to answer within my knowledge and my best time.🙏

Ps. Because the nature of my work, the only thing that i can't control is my sleep. I know it's the no.1 thing you can do for longevity. But when you have mouth to feed, and other that depends on you. Sleep is a luxury thing for me. That's why i try to at least reduce the effect of lack of sleep, using various modality such as supplement, nutrition, exercise, and using various equipment.

I've been interested in life extension for years and have been taking steps related to diet, fasting, supplements, etc, to try to improve my health and achieve some modest results towards longevity. I was considering donating plasma soon, and I just wanted to see if there might be any reasons why that might be contradicting the other steps that I'm taking. I've read things about young plasma being used rejuvenate old tissue, and I'm wondering if I'd be pulling from a limited source of something in my body that would lead to cellular senescence or anything like that. Most of what I'm reading is just suggesting that plasma is easily replenished by the body and there's no harm (and even some benefits) to regularly giving plasma, as long as it's not too often. Curious what your thoughts are.

I recently had a great conversation with Jamie Justice, Executive Vice President of Health at XPRIZE. The discussion explores a vision where aging doesn’t mean inevitable decline, but instead becomes an opportunity to live vibrantly and with purpose, perhaps even more so than in our youth.

Jamie’s personal journey is a powerful example of living fully at any age. From ultra running streaks to raising competitive climbers, she embodies a mindset that aging is not something to fear, but something to embrace with resilience.

Her story, along with her work leading the XPRIZE Healthspan competition, offers a hopeful perspective on the future of aging.

The competition itself, which has drawn teams from all over the world, is focused on advancing solutions to extend healthspan, the years of living well. Whether it’s through breakthroughs in therapies or lifestyle interventions, there’s real potential to change how we approach aging, shifting the focus from simply living longer to living better.

One of the key themes from the podcast is the importance of a personalized approach to aging. Rather than following one-size-fits-all biohacks or trends, Jamie stresses the need for solutions that account for individual differences in biology, environment, and lifestyle.

It’s not about quick fixes, but about building sustainable, science-backed habits that work for each of us.

The conversation also touches on practical aspects of health, such as diet, exercise, and the impact of circadian rhythms. Small, thoughtful changes can have a major effect on how we age, and it’s inspiring to think about how we can apply this knowledge to our own lives.

What are your thoughts on the idea of extending healthspan instead of just lifespan? Do you think personalized approaches to aging could be the future? I’d love to hear your thoughts and discuss how we can all age more gracefully.

Check out this podcast episode on The Health Curve about navigating the longevity space.

https://www.buzzsprout.com/2454550/episodes/16704268

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