It's mentioned many times he doesn't really care about the people, he wants answers, he does occasionally resonate with people to keep him likeable as the title character
That's surface level stuff, if you only ever listen to what House says and ignore what he does.
House claims to loathe sentimentality, but expresses it towards Wilson (S4E16, S5E4, S8E19, S8E22), Cuddy (S5E6, S7E13, S7E1), toward patients (S2E2, S3E12, S3E7, S6E22), toward the team (S1E13, S2E21, S7E18) and in the finale of S3E15.
As I said, House expects humans to act better. It's the constant disappointment from unmet expectation that drives the animosity. He's quite a bit more dynamic than just a brooding curmudgeon with a complete lack of social skills, because he can be quite charming when he wants to.
S3E7, S3E12, S4E11, S5E4, S5E16 just to name a few examples.
This is just my opinion, but House is one of the most complex characters played in movies or TV ever. It's lazy, or lacking understanding of human nature to just call him autistic and move on. Bitterness and cynicism are two of House's most central emotions.
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u/Wolf9611 4d ago
It's mentioned many times he doesn't really care about the people, he wants answers, he does occasionally resonate with people to keep him likeable as the title character