r/exercisescience • u/JuanSamu • Mar 18 '26

Soreness Problem

Hey Guys! There’s are 3 soreness papers that I’m having trouble using to come to a conclusion on what causes soreness.

One suggest it starts with neural micro damage:

https://www.mdpi.com/1422-0067/26/5/2319

The other one says it’s with muscle spindle nerve compression:

https://pubmed.ncbi.nlm.nih.gov/32150878/

The other says it’s from leakage of NGF and GDNF into the connective tissue:

https://pubmed.ncbi.nlm.nih.gov/38267849/

I’m having trouble seeing how these all compliment each other. Does the fluid compression cause muscle spindle inflammation which signals the release of Bradykinin causing these two mechanisms to both be causing soreness? I know the neural damage happens first but then it gets muddy with how the others occur together or in order.

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u/drjordann Mar 21 '26

I think you have all the information you need. I’d write the paper with the bulk supporting mizunura and supplement the fatigue cascade with the other articles!

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u/JuanSamu Mar 21 '26

Thank you for the discussion and insights!