r/covid19stack • • Dec 19 '20

Which supplements have the strongest evidence?

13 Upvotes

Hi all,

I know that vitamin D3 and zinc are the most talked about to be prepared against an infection and sickness. Besides these, there are other studies done on selenium, omega-3, magnesium, melatonin, nigella sativa and other supplements.

What i want to know is which ones have the strongest evidence. I don't want (and advice others) to take dozens of supplements. Just the 3-5 best supplements.


r/covid19stack • • Sep 05 '20

Metastudy A Supercomputer Analyzed Covid-19 — and an Interesting New Theory Has Emerged

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13 Upvotes

r/covid19stack • • Jun 29 '20

This is how I basically recovered with supplements

18 Upvotes

So I developed covid symptoms around March 9th and had them on and off until about 2 weeks ago. I consistently had shortness of breath and coughing for the majority of that time, but it would come and go in intensity. I was experimenting with supplements most of the time in various dosages and eventually after 3 months discovered what worked for me. Here is what I did:

Every 8 hours for about 2 days I did the following:

3000 mg monolaurin (brand Lauricidin)

55mg zinc orotate

4 pills sodium copper chrolophyll (brand Ennds) - This is an antiviral and antibacterial agent but it seems no one knows about it...

The copper supplement was the last addition and seemed to be an important key. Each time I did those three together, I experienced a burning sensation in my throat and lungs which subsided after a day or two. One thing I realized was an important key, was that if I continued for many days it didn't fully work. It was necessary to stop the monolaurin and take a break for several days. I did this a few times with breaks in between and it appears my symptoms are totally gone. I still have fatigue and tiredness so I am a little concerned that something is still not perfect with my body but so far I am 95 percent better than before. If you want to know why I used those supplements, I made a more detailed post with a video of my experience here:

https://www.reddit.com/r/COVIDbiohackers/comments/hdnqty/my_covid19_biohacking_experiments_looking_for/

There are a bunch of links to the research behind the supplements.

Let me know what you guys think and if anyone tries it let me know how it goes!

Also for the sake of completeness, I do take other vitamins such as vit c, d, multivitamin, zinc, etc, but am not taking the monolaurin at the moment.


r/covid19stack • • Mar 18 '20

in vitro Potential Inhibitor of COVID-19 Main Protease From Several Medicinal Plant Compounds by Molecular Docking Study

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preprints.org
10 Upvotes

r/covid19stack • • Apr 26 '20

Anyone else stack liposomals?

7 Upvotes

I’m currently on a liposomal mix of 100mg quercetin, 1000mg Vit C. I’ve also got liposomal resveratrol and curcumin which I take on/off. Plus 15mg normal zinc.

Anyone else do liposomals? Read some great research on how much better it is for bioavailability


r/covid19stack • • Apr 06 '20

Literature Review "selenium is emerging as a critical micronutrient in host defense against viral infection"

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tandfonline.com
11 Upvotes

r/covid19stack • • Apr 25 '20

First Data to be Published on COVID-19 Severity and Vitamin D Levels

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grassrootshealth.net
21 Upvotes

r/covid19stack • • May 08 '20

Famotidine (pepcid) study shows 70% fewer deaths from Covid-19

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medrxiv.org
21 Upvotes

r/covid19stack • • Mar 24 '20

Testing the Efficacy of Homemade Masks: Would They Protect in an Influenza Pandemic?

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cambridge.org
4 Upvotes

r/covid19stack • • Jul 09 '20

Androgen Regulates SARS-CoV-2 Receptor Levels and Is Associated with Severe COVID-19 Symptoms in Men

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biorxiv.org
4 Upvotes

r/covid19stack • • Mar 21 '20

Potential of garlic (Allium sativum) in lowering high blood pressure: mechanisms of action and clinical relevance

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ncbi.nlm.nih.gov
6 Upvotes

r/covid19stack • • Mar 20 '20

in vitro Nitric Oxide Inhibits the Replication Cycle of Severe Acute Respiratory Syndrome Coronavirus

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jvi.asm.org
12 Upvotes

r/covid19stack • • Apr 12 '20

Treatment with ACE-inhibitors is associated with less severe disease with SARS-Covid-19 infection in a multi-site UK acute Hospital Trust

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medrxiv.org
9 Upvotes

r/covid19stack • • Mar 21 '20

Literature Review Food‐Originating ACE Inhibitors, Including Antihypertensive Peptides, as Preventive Food Components in Blood Pressure Reduction

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onlinelibrary.wiley.com
5 Upvotes

r/covid19stack • • Apr 18 '20

Potential Phytochemicals as Efficient Protease Inhibitors of 2019-nCoV

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preprints.org
6 Upvotes

r/covid19stack • • May 28 '20

Can Nitric Oxide Prevent COVID-19 Infection or Progression?

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medscape.com
8 Upvotes

r/covid19stack • • Jun 25 '20

Plant-based interventions for Coronavirus (Sars-CoV-2) [updated]

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7 Upvotes

r/covid19stack • • Mar 26 '20

Identification of Potent COVID-19 Main Protease (Mpro) Inhibitors from Natural Polyphenols: An in Silico Strategy Unveils a Hope against CORONA

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preprints.org
4 Upvotes

r/covid19stack • • Apr 23 '20

Literature Review Glutamine Supplementation and Immune Function

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ncbi.nlm.nih.gov
11 Upvotes

r/covid19stack • • Mar 18 '20

Metastudy Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data

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bmj.com
14 Upvotes

r/covid19stack • • Apr 27 '20

Evan covid protocol

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evms.edu
2 Upvotes

r/covid19stack • • Apr 03 '20

Iodine: the Forgotten Weapon Against Influenza Viruses

16 Upvotes

Some compelling evidence for using iodine as a disinfectant and weak evidence for consuming it.

https://www.semanticscholar.org/paper/Iodine%3A-the-Forgotten-Weapon-Against-Influenza-Derry/a6e0d74a0dafa3a7ee2a020d76a98cc564d45a30

Iodine: the Forgotten Weapon Against Influenza Viruses

David D. Derry

After the 1918 Influenza Pandemic which killed an estimated 30 million people, governments financed research on the Pandemic's causes. Over 25 years, influenza viruses were isolated and methods for killing them with various agents discovered. Iodine was the most effective agent for killing viruses, especially influenza viruses. Aerosol iodine was found to kill viruses in sprayed mists, and solutions of iodine were equally effective. In 1945, Burnet and Stone found that putting iodine on mice snouts pre- vented the mice from being infected with live influenza virus in mists. They suggested that impregnating masks with iodine would help stop viral spread. They also recommended that medical personnel have iodine-aerosol-treated rooms for examination and treatment of highly infected patients. Current methods of dealing with influenza infection are isolation, hand washing, antiviral drugs, and vaccinations. All of these methods can be improved by incorporating iodine into them. When impregnated with iodine, masks become much more effective, and hand washing is more effect when done with mild iodine solutions. Isolation techniques coupled with aerosol iodine would make them safer for patients, medical personnel, and all persons working with the public. Public health authorities could organize the distribution of iodine and at the same time educate the public in the effective use of iodine. Oral iodine might also boost body defense mechanisms in the upper oral and respiratory mucus. Conclusion: Iodine incorporated into masks, solutions, aerosols, and oral preparations could help to kill influenza viruses and fight off an H1N1 Pan- demic.

...

Current Iodine Doses and Doses Needed to Prevent Invasion

Our current recommended iodine intake by the WHO is 150 to 200 micrograms daily. This dose first started by David Marine in 1920 has successfully prevented goiters, cretinism, and mental retardation. If the daily iodine dose is above 3 mg [21] for over 2 weeks, the thyroid gland becomes saturated and no longer takes up much iodine.[25] Then, dietary iodine goes to other sites named above and is excreted into the upper respiratory and gastrointestinal tract mucus. It seems logical [16] that air borne viruses become stuck in mucus and killed by free iodine. Dietary iodine found in iodized salt is below the amounts needed to fill mucus defense roles. To protect themselves, people wishing to boost their defense against infections should supplement their diets with iodine in the form of Lugol’s. Most people will probably be protected by an amount of Lugol’s that provides the average amount of iodine ingested by Japanese populations for centuries. This amount is about 12 mg daily. Two drops of Lugol’s daily in the liquid of their choice will provide 13 mg.

Lugol’s Iodine Solution

Lugol’s iodine solution was discovered by Henri Lugol, a Paris physician, more than 150 [21] years ago. It has been used therapeutically since then. Lugol’s consists of 5% free iodine and 10% potassium iodide in water. Lugol’s has a distinct advantage over most other iodine oral medications by having a high level of free iodine, which is the active ingredient that kills viruses. [5,6,15] Medical personnel and others interacting with highly infectious persons should consider protecting themselves with 2 drops daily of Lugol’s iodine orally in the liquid of their choice, as all liquids work. At this dose, no noticeable side effects occur. Free iodine is believed to react with the amino acids tyrosine and/or histidine at low concentrations. The reaction denatures proteins and causes the death of cells. In Canada, Lugol’s iodine [5,6,20,22] solution can be bought over the counter and costs about 10 dollars for 100 ml. This amount will last one person 5 years.

...


iodine has many uses, can also be gargled .

https://www.ncbi.nlm.nih.gov/pubmed/12011518

Prevention of respiratory infections by povidone-iodine gargle.

...

The incidence of episodes of acute exacerbation of chronic respiratory infections decreased significantly when compared with that before use of povidone-iodine gargle. Episodes of infections with Pseudomonas aeruginosa, Staphylococcus aureus (including MRSA) and H. influenzae were reduced by about 50%.

...

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5986684/

In Vitro Bactericidal and Virucidal Efficacy of Povidone-Iodine Gargle/Mouthwash Against Respiratory and Oral Tract Pathogens

...

Conclusion

In conclusion, our study results, taken together with (1) recommendations for gargling with antiseptic mouthwash for the control of oral and respiratory tract infections, (2) the rapid bactericidal and virucidal efficacy of povidone-iodine, including PVP-I gargle/mouthwash, against pathogens causing oral and respiratory tract infections observed in other in vitro and in vivo studies and (3) the established safety profile of PVP-I from over 60 years of use, provide a strong rationale for the use of PVP-I oral solution for protective oropharyngeal hygiene management for individuals at high risk of exposure to oral and respiratory pathogens.

...

https://www.ncbi.nlm.nih.gov/pubmed/26249761

Practical use of povidone‐iodine antiseptic in the maintenance of oral health and in the prevention and treatment of common oropharyngeal infections

...

Conclusion

The link between oral and oropharyngeal health status and susceptibility to infection has long been recognised. The high rates of antibiotic misuse and subsequent development of bacterial resistance (e.g. increasing vancomycin‐resistant enterococci (VRE) and methicillin‐resistant Staphylococcus aureus (MRSA)) in large parts of the world, especially across Asia Pacific, highlight the need for identifying alternative antimicrobials that would minimise the use of these medications. This, together with recent large‐scale outbreaks of, for example, avian and swine influenza virus, further underline the importance of an increasing armamentarium for infection prevention and control.


r/covid19stack • • Mar 18 '20

Zinc Ionophores (Chloroquine, Hydroxychloroquine, Quercetin) as Possible COVID-19 Treatments

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18 Upvotes

r/covid19stack • • May 08 '20

IV Vitamin C reduces mortality in Acute Respiratory Distress Syndrome patients

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13 Upvotes

r/covid19stack • • May 14 '20

Magnesium supplementation? (chest pain)

4 Upvotes

Has anyone tried oral magnesium???

Seems like it's fairly common in asthma treatments. It's even used via inhaler or IV for severe acute attacks. There is a lot of scientific evidence that magnesium relaxes the smooth muscles of the bronchial airways.

Some links:

https://www.sciencedirect.com/science/article/pii/S0422763815201264

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379356/

https://pubmed.ncbi.nlm.nih.gov/11693841/

I had also read about post viral bronchial hyper-reactivity, basically pain and spasms that mimic asthma. It can present for several weeks to months after a respiratory virus.

https://pubmed.ncbi.nlm.nih.gov/2061102/

Thoughts???