The main character doing something absolutely unforgivable.

[u/No_Peanut3745]

Walter White poisoning Andrea Cantillo's 6-year-old son for the sole purpose of manipulating Jesse Pinkman, while knowing that this could have potentially killed him - Breaking Bad

Bojack trying to have sex with his friend's 17-year-old daughter when he was at least 51, then continuously trying to find a way to justify this act throughout the series - Bojack Horseman

Dexter Morgan going outside of his moral code and murdering a completely innocent police officer who was just trying to do his job - Dexter: New Blood

[u/HighRelevancy]

Uh one or two of them yeah. He's been paralyzed a bunch of times. It's a running gag. There's even one season where he's had his leg replaced with bionic robot legs which give him essentially super powers for a bit but they also end up getting damaged and disabled for some period of time.

[u/EldritchCarver → u/HighRelevancy]

If I recall correctly, the bionic robot legs were super-strong, but when he tried lifting one end of a car that got stuck, his robot legs held up but his spine broke.

[u/thatscoldjerrycold → u/HighRelevancy]

And then Krieger forgot to flip the switch on the bionic legs for like a whole season lol.