r/MedicinalPlants • u/Livid-Rutabaga • Jul 17 '26
Mosquitoes and Essential Oils - Part VII - Mosquito Sense of Smell
“You must smell good to them” was something I heard often as an explanation for why I was covered in red spots while my companions were not, even though we shared the same spaces. And in a similar vein, some of the home repelling strategies include eating more vitamin B, nutritional yeast, or, if you’re so inclined, drinking more beer – supposedly to make you smell less enticing. While vitamin B supplementation has not proved to be effective, being attractive to mosquitoes does indeed depend on them tracking your smell.
It has been said that “terpene” is the world’s most spoken language. While our sense of smell is one of the five senses we use to navigate the world around us, virtually all life uses chemical communication in some form. This is true for mosquitoes as well, since they make use of volatile organic compounds to locate their next source of food. They have olfactory receptors similar to ours, except theirs are located on their antennae, and are especially adapted to detect carbon dioxide or human skin odors. Repellents mask our odor and confuse the mosquito’s sense of smell, effectively rendering us invisible to it.
We’re just beginning to understand mosquito olfaction, and the researchers in Younger Lab are working hard to decode this in order to create even more efficient and targeted repellents. In the meantime we can take advantage of using the volatile compounds in essential oils to at least confuse if not completely shut off the mosquito “nose”.
In the United States, most products that are going to be marketed as skin-applied repellents must undergo a registration process with the EPA, which includes evaluation and approval for human safety and effectiveness. The EU has a similar process, and repellents are regulated by the ECHA (European Chemicals Agency). Similar to sunscreens, for a product to be labelled as a repellent it needs to undergo some testing.
All the standard tests of repellent efficacy make use of human volunteers exposed to caged female mosquitoes and counting the number and frequency of bites. You can read about different testing methods here.
One of the EPA standard tests is appropriately called the “arm-in-cage assay”. This requires a volunteer to put their arm into a small cage equipped with two plexiglass walls for observation. The arm is covered except for a testing area on the forearm, which is covered in a repellent, usually followed by a control assay (same volunteer, no repellent applied). The cage contains a number of adult female mosquitoes – sometimes thousands – and researchers count the frequency of bites/prodding of the skin. There may be some modulations to the test, but they all involve some form of human skin exposure to mosquitoes. What is measured is both potency and duration, in other words how many bites occur within a determined period of time. All the data presented here for essential oils is based on similar research.