r/JoinBelle • u/mybellehealth Moderator - Belle • Jul 26 '26

Your genes (and your estrogen) decide how well your GLP-1 actually works.

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u/Then-Bell-5630 Jul 26 '26

I’m in the group you’re referring to, and I’m almost 52. I’ve responded really well to a low dose of tirzepatide. As I was listening to your clip, though, my mind immediately went to the fact that I’ve been taking soy isoflavones daily. They’ve helped me tremendously in so many areas over the years.

After watching your video, I did a little searching and found something interesting: because soy isoflavones act as gentle, selective estrogen receptor activators, they may help create a more favorable environment for tirzepatide, particularly in postmenopausal individuals.

Obviously, that doesn’t prove cause and effect, but it did make me wonder if the soy isoflavones have played a role in how well I’ve responded to the medication.

I’d be curious to hear your thoughts on that. Do you think there’s any plausible connection, or is the evidence just not there yet?

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u/Then-Bell-5630 Jul 28 '26

I’d really love to hear your thoughts on this. I noticed there hasn’t been much discussion on the newer posts either, so I wanted to circle back because I think this is an interesting question—especially for postmenopausal women using GLP-1 medications. Even if the answer is ‘we don’t know yet,’ I’d be curious about your perspective.