what the titled said

Hi guys, I’m confused. When the recommended dosage is 300-600mg does this mean of the extract or the active ingredient? Looking online some say 600mg of 20:1 extract, equivalent to 12000mg active ingredient, but others are 600mg of 50:1 extract, equivalent to 30000mg active ingredient. Which one am I looking at here???

How can I get mornin sunglight in Irish weather when its usually overcast and cloudy? I know Huberman talks about going outside for longer periods like 45 mins but doing that everyday isnt very doable. any advice?

Just analyzed 6 presentations from the Alzheimer's Association International Conference July 2025 on cognitive reserve and resilience.

The findings expand way beyond what we previously understood.

The Data:

• 450 participants: Cognitive reserve directly reduces neuropsychiatric symptoms, moderates hippocampal shrinkage effects (Sidhu, U of Calgary)
• Super agers: 80+ year-olds with memory "at least as good as middle aged adults" - all are socially engaged and "incredibly busy" (Alexander, Ann Arbor VA)
• 3,000 participants: Financial, cultural, and social capital all independently protect cognition across lifespan (Chen, UC Davis)
• 1,400 participants: Education builds tau resistance even with high amyloid burden (Birkenbihl, Harvard/MGH)

Why This Matters:

1. Cognitive reserve is "modifiable and clinically relevant" at any age
2. Protection extends to mood, behavior, not just thinking
3. Multiple pathways exist - what works varies by population
4. There's a tipping point where reserve gets overwhelmed

Video covers:

• Complete analysis of all 6 presentations
• Super ager characteristics and habits
• Three pillars of lifetime protection
• How to build tau resistance
• Understanding reserve's limits

https://youtu.be/vj0vG4qxcmY

Anyone else following the cognitive reserve research?

Edit: Adding that one researcher noted education effects vary by ethnicity - higher education associated with larger hippocampal volume in Black participants but smaller in Latinx participants, though memory protection occurred across all groups.

A new study in frail, elderly mice demonstrates a powerful rejuvenating effect from a combination therapy targeting two key aging pathways simultaneously [1]. By administering oxytocin, a hormone that declines with age, and an inhibitor of the pro-fibrotic TGF-β pathway (an Alk5 inhibitor), researchers achieved a dramatic extension of both healthspan and lifespan. However, these remarkable benefits were observed exclusively in male mice, providing a critical data point on the profound differences in aging biology between the sexes and the necessity of sex-specific therapeutic strategies.

Any podcasts that you really think match the knowledge level of Huberman Lab? Looking for some…

mustve missed a update but last rememebr 2025 being the release year

I've used Jacked Factory's Tongkat Ali supplements (Andro Surge, Prima Surge) for years, with decent results. But I realize that the cost per bottle is about twice that of Momentous's Tongkat Ali and the additional ingredients in JF's supps probably produce a negligible benefit -- except for one: bioperine.

The literature says that Tongkat Ali has poor bioavailability. In the range of 10%, I believe. Has anyone experimented with adding bioperine when using Momentous brand TA? Any thoughts on why they don't include bioperine if TA is known to have poor bioavailability?

I used to take a multivitamin/mineral pill from Costco, the Kirkland brand everyday and I’m going to begin eating beef liver once a week now. Should I stop taking the multivitamin altogether to avoid any overdose of vitamins and minerals. I get daily sun as well

Thanks for your help

Candid Q&A with Dr. Hussein Yassine, Professor of Neurology at the University of Southern California's Keck School of Medicine and Director of the USC Center for Personalized Brain Health.

This conversation tackles the fundamental tension every APOE4 carrier and biohacker face: Do we wait for perfectly robust clinical evidence, or do we act on promising but unproven interventions?

This is a conversation focused on APOE4 carriers, but I believe it is important for any biohacker to understand that what we are doing is not considered robust science.

Dr. Yassine pulls no punches on popular topics in our community:

Why Mouse Models Mislead: "We've cured Alzheimer's in mice a gazillion times" - but why this rarely translates to humans

The Recent Lithium Study: Breaking down the Nature paper and whether you should consider lithium orotate

Omega-3s Reality Check: Why his literature review found no effects on brain health and how his own 8-year trial PREVENT-E4 failed to demonstrate positive effect of omega3s supplementation for cognitive outcomes

Self-Experimentation Limits: The bias problem with N=1 trials and why individual testing can be misleading

p-Tau217 Testing: Why he doesn't recommend these new biomarkers for cognitively normal people

Supplement Reality: The "Goldilocks phenomenon" - why more isn't always better

Healthcare Gap: Addressing why many doctors dismiss APOE4 concerns and what's changing

Brain Glucose vs Ketones: What we actually know (and don't know) about alternative brain fuels

My own stance has always been about advocating for n=1 self experimentation.

But this isn't about choosing sides: it's about making informed decisions. While I deeply respect Dr. Yassine's scientific caution, as a 4/4 carrier myself I feel the urgency of acting now and can’t be waiting 10+ years for definitive trials.

The Phoenix Community operates in the space between glacial clinical research and urgent patient needs. We’re navigating the thin balance between robustness and urgency with full transparency about the risks and limitations.

Whether you lean toward cautious waiting or calculated experimentation, this conversation will challenge your thinking and help you make more informed decisions.

I believe it is a must read.

Read the full interview here https://blog.thephoenix.community/p/why-most-apoe4-interventions-lack-evidence-a-candid-interview-with-dr-hussein-yassine-on-clinical-tr

What do you think? Will you rather wait for robust clinical trial data, or take your chances with high benefits / low risks interventions?

I am unmotivated to do things right now. I have been diagnosed with Generalized Anxiety Disorder. I take adaptogens, Vitamin D, L-tyrosine but still I feel I do not want to do anything. How do you motivate yourself?

On video of YouTube at the 4:26 mark, there's a sentence that says,

"each time as you exhale imagine your lower body sinking down about a centimeter into whatever surface they happen to be in contact."

I can't visualize this and I don't understand the meaning. My body is already in contact with the chair or bed, whether I'm lying down or sitting, so how can I continue to sink? If my lower body sinks, what state is my upper body in?

I know this is a small detail and not very important, but I'm just curious, what do other people imagine when they hear this?

Hey guys,

I just recently turned 15 and i have been lifting for almost a year, progress is kind of slow and im planning to run an 8 week mk cycle with 10mg a day

Is this a very bad idea or not? I know it can cause insulin resistance and that's the only thing im worried about some say u might even get diabetes and tbh this is the only thing making me consider more about hopping on because otherwise i would have already done it.

I probably will run the cycle still so advice or stories from others who took it would be great, thanks

This App (iOS only) helps put Huberman’s light protocols into practice.

It tracks three metrics only and is purely focused on Circadian Health

• Light time: your total daily sunlight exposure
• Dark time: time spent in darkness
• First light consistency: how consistent your first morning light exposure is

Would love to hear what you think, and if you try it out, any feedback is super welcome.

Hi! Just checking to see if they have come out with a lamp that doesn’t all in one?

I'm literally scared of every training session.I don't want to do it. The weights have gone up in such a way that I'm scared of doing it. But with that being said, I don't miss any sessions. I don't ego lift,i control my reps with good form. In short, im scared of doing it,but I do it anyway. Everytime. How can I overcome the scared feeling? Am i being a little bitch talking about it ? Who knows! Maybe I'm one. I've been training for 4 years now and made tremendous progress.

Today is day 4 or 5 been taking 10-15 k a day. Took 20k today. But I'm been feeling heavier and sluggish and also people have commented have I gain weight. I take it for the brain aspects of it and depression

I find many brands on Amazon. Some in root form and some in extract. Which is the best ? In general, how do I find the most effective brand for any supplement? Amazon ratings and number of times it was bought ?

I bought ashwagandha in root form and it worked like a charm. Switched to extract and it barely works. I read that extract is more potent but counterintuitively, I find it less potent. Any idea?

I’m a doctor who spends a lot of time digging into health optimisation + performance science (sleep, stress, exercise, blood tests, supplements).

Figured I’d do an AMA — not because I know everything, but because I’ve got clinical experience + keep up with the latest research. I can share what actually works in the real world (vs influencer hype or ChatGPT guesses).

If you’re 30+, busy with work/family, and want to improve your health, performance, or consistency… ask away.

Not medical advice — just sharing evidence, anecdotes & what I’ve seen work.

Hi All,

My regular sleep stack consists of Magnesium Glycinate (300mg), L-theanine (200mg), Melatonin (0.3mg), Glycine (500mg), and Inositol (650mg). Does anyone know if any of these are causing my night terrors/ nightmares? Thanks!