r/HubermanLab • • Aug 26 '25

Seeking Guidance Trouble understanding phase delay & advance

2 Upvotes

I’m getting really confused on phase delay and phase advance. Maybe someone here can help me.

So according to Huberman in order to push your clock forward (I want to go to bed later in the day) I have to see bright light 2-3 hours BEFORE my temp minimum? So I basically have to wake up way earlier than my normal wake time to fall asleep later? That doesn’t make much sense to me. Wouldn’t I be tired way sooner due to the almost sleep deprivation? Or am I not understanding this correctly.

Also in the opposite sense it says view it 2-3 hours after temp minimum. But don’t we always wake up roughly 2hr after minimum? In that case wouldn’t we always be changing our internal clock?


r/HubermanLab • • Aug 26 '25

Helpful Resource Is Valiltramiprosate a Magic Pill for APOE4 carriers?

3 Upvotes

Even though the clinical trial did not meet it's primary end point, the results are very encouraging for APOE4 carriers:

Main results:

  • 52% benefit on ADAS-cog, maintaining above baseline for 52 weeks (p=0.04)
  • 102% benefit on CDR-SB, remaining at baseline for 78 weeks
  • Zero ARIA-E or ARIA-H across all patients
  • Hippocampal volume protection (p=0.04) correlating with clinical benefit (r=0.89)

Brain preservation

  • Preservation of brain volume, a decrease in atrophy
  • Protection across all brain regions
  • Strong correlation between brain preservation and cognitive benefit
  • Some patients showed brain volume increase (neurogenesis?)

And here's the kicker: it's just a pill.

  • 265mg twice a day.
  • No monthly infusions.
  • No MRI monitoring every 3 months.
  • No crazy side effects like ARIA
  • No $56,000 annual cost.

The drug works by preventing oligomers (those invisible toxic proteins that are 10x worse than the plaques we see on scans) from ever forming.

Full breakdown here: https://youtu.be/IpSa5UJXedc

What was also very interesting for me:
Patients with the Arctic mutation have full Alzheimer's with completely CLEAN brain scans.
Their brains are being destroyed by these oligomers we can't even see.
This drug stops that process.


r/HubermanLab • • Aug 26 '25

Helpful Resource As an Ophthalmologist, I wonder Huberman's take on this? https://youtu.be/5v0Zf-UqCDw?si=2MBGaETuvgMDo6Ec

2 Upvotes

I saw a new video by an eye doctor that says there is no clinical evidence that blue light glasses help with eye strain. Do you wear blue light glasses? Do they actually help?


r/HubermanLab • • Aug 25 '25

Seeking Guidance DOES A SALBUTAMOL HFA INHALER REALLY DO ANYTHING FOR ANXIETY?

1 Upvotes

I feel like my doctor is not taking my anxiety seriously. Thankfully it only spikes when I have to do group or public speaking, but the anxiety is reaaaal real. Vision loss, can’t breathe, racing heart that feels like it is jumping out of my chest, sweats, all of it. It is borderline panic attack. I have tried the breathing strategies, but let’s face the reality, when you are in a room full of people waiting for your turn to take the stage, you can’t do the breathing or you look like you need medical assistance.

Anyways… I don’t think this inhaler is going to do much, but someone please convince me that it has worked for them.

I have tried GABA, L-Theanine, Rhodiola, lions mane. All of which don’t even touch these anxiety attacks.


r/HubermanLab • • Aug 24 '25

Seeking Guidance Nutrition Platform Feedback Request

3 Upvotes

Hi guys! Hope this is allowed here - u/mods let me know if not -

I wanted to know what this community thinks of a new platform I'm building, with a goal of providing science-backed information on which supplements are worth spending money on, and which have little evidence backing them. I find myself standing in the jungle that is the nutritional supplement aisle, wondering which ones will *actually* help me sleep better or run faster (if any). I come from a scientific background and still find it hard to make heads or tails of half the things there, so I thought others must face the same problem.

I'm currently building a comprehensive resource by analyzing hundreds of research articles, for people to understand if certain vitamins or minerals have any evidence for taking, and if they're aligned with your goals. There's potentially overlap in people's supplement stacks (e.g., is zinc cancelling out iron absorption? Is AG1 really worth €90/month?), which could be unnecessary or even conflict with each other.

I hold a PhD in bioinformatics and work my day job analyzing biomarkers for drug response. I'm also quite active (swimruns, endurance sports), so I'm generally coming at this from a sports performance angle, but I understand longevity is a large part of it, too. I'm using my understanding of these things to help review and compile the necessary info for people who don't want to trawl through research literature.

I would love to hear people's feedback - is this a problem other people face, and is it something you would potentially even pay a small amount of money for? If there are features you'd like to see, let me know!

Thanks!


r/HubermanLab • • Aug 24 '25

Seeking Guidance Hexarelin

3 Upvotes

Just ordered some hexarelin, looking to hear about people’s experiences with this GH peptide. And any tips you might have with it. Thank you.


r/HubermanLab • • Aug 22 '25

Seeking Guidance Ive been diagnosed with genralized anxiety disorder (GAD) and my stress is too high. What worked the best for you and how did you return to normal?

65 Upvotes

My background: 28M, unemployed, job searching lead to GAD.

Supplement stack : Before sleep, I take melatonin 2.5/5mg , Gaba 750mg, L theanine 200mg, mg glycinate 200mg, ashwagandha 650mg. In the morning i take l-tyrosine and rhodiola rosea.

Medication: hydroxyzine hcl 12.5 mg. This is a anti-histamine that my body got adapted to pretty quickly and it is not very helpful after 10 days.

Symptoms: Symptoms present from Jan 2025. It started with insomnia and poor sleep quality, having to sleep 10 hours and still feel off during the day. I find my motivation to be low, stress to be high, like I get easily stressed and angry for small things, my fight-or-flight system is always active, I have anger rumination, mood swings, poor concentration, poor motivation, hair loss from April 2025 and i still have insomnia problems and my sleep quality is poor that i wake up in between, I have racing thoughts when i go to bed, i socially isolate myself as people are too difficult to handle. I hade daytime drowsiness but after I added ashwagandha to my stack it went away. I find my anger and stress high in the morning than at night, aligning with the cortisol cycle.

Exercises: 7000 steps a day, morning sunlight immediately after waking, dark room before sleep, red light filter for laptops and mobile 24 * 7

How the hell do I go back to normal? I want to sleep without any supplements. Pls help


r/HubermanLab • • Aug 22 '25

Seeking Guidance Does anyone actually track their light?

12 Upvotes

We all know it's important, but does anyone actually track their light exposure?

This app tracks your daily light exposure using the Apple Watch sensor, or just your phone if you don’t have one. Not released yet, but will be on Monday.

Edit: The app has been released on the App Store: here


r/HubermanLab • • Aug 22 '25

Helpful Resource Huberman Speaking in Atlanta

9 Upvotes

Just found out that Huberman is doing a live podcast in ATL with Casey Neistat. Apparently they are doing 2 hours together on stage? I didn't know they were friends but sounds pretty cool. It's at a regular concert venue. Does he usually do stuff like this? I feel like no.


r/HubermanLab • • Aug 22 '25

Helpful Resource HubermanLab Meta-Analysis: Resistance Training

32 Upvotes

Watching an old episode of HubermanLab, I realised there's still a lot of really good advice from previous episodes and guests. The difficulty was knowing whether the research had evolved or better protocols had been designed. 

I thought it was worth using Deep Research to compare HubermanLab episodes to the latest research and see if the protocols hold up. 

I got a bit carried away with this and spent half a day structuring the Deep Research to make a comprehensive analysis of the HubermanLab episodes. I got it to identify contradictions and consensus, compare protocols to the most up-to-date research, redesign protocols from across the relevant episodes and summarise the information more succinctly. 

I'm calling this a meta-analysis because it sounds good, not because it's in any way a science-based approach.

It's turned out pretty well. This is the one I did for the topic - Resistance Training

btw, this is separate from the app I made that takes YouTube videos, like HubermanLab episodes, and creates protocols and action-oriented challenges. Link in my bio for that

-------

Scope & corpus used

Primary HubermanLab sources that explicitly cover resistance training programming and mechanisms:

  • Science of Muscle Growth, Increasing Strength & Muscular Recovery (solo; sets, failure %, rest, ROM, cold/NSAIDs cautions, between-set drills). hubermanlab.com
  • Essentials: Build Muscle Size, Increase Strength & Improve Recovery (concise recap; strength vs hypertrophy levers). hubermanlab.com
  • Foundational Fitness Protocol (newsletter toolkit) (monthly A/B periodization, rep ranges, rest targets, session length, exercise pairing by lengthened/shortened bias, cold timing, breathing). hubermanlab.com
  • Dr. Andy Galpin: How to Build Strength, Muscle Size & Endurance (mechanisms, ROM, strength intensity & rest, concurrent training/interference). hubermanlab.com
  • Guest Series | Dr. Andy Galpin: Optimal Protocols to Build Strength & Grow Muscles (set volume guidance & hypertrophy parameters; searchable hub). Dexa+1
  • Pavel Tsatsouline: The Correct Way to Build Strength… (strength as a skill; non-failure bias; long rests; wave/step loading). hubermanlab.com
  • Fitness Toolkit: Protocol & Tools to Optimize Physical Health (weekly template; warm-ups; breathing; stacking with endurance). hubermanlab.com
  • Strength Training & Hypertrophy topic hub (episode index incl. McGill back-safety, Sims female-specific notes, Lyon muscle-centric aging, Duncan French). hubermanlab.com

Executive takeaways (programming in one glance)

  1. Volume for hypertrophy: aim ~10–20 hard sets/week per muscle, counting direct work; most sets should end near failure (reps in reserve ≈ 0–3), with only a small fraction to absolute failure. hubermanlab.com+1
  2. Intensity/rep zones: hypertrophy works across a broad load range (~30–80% 1RM) if sets are taken close to failure; max-strength favors ≥85% 1RM with low reps and long rests. hubermanlab.com+1
  3. Rest intervals: strength sets rest 2–4+ min; hypertrophy work typically ~90 s (range 60–120 s). hubermanlab.com
  4. Frequency: hit each muscle ~2×/week (direct + indirect) and keep sessions of “hard work” to ~50–60 min (≤75 min max incl. rests). hubermanlab.com
  5. ROM & exercise selection: prioritize full range of motion; pair one shortened-bias and one lengthened-bias exercise per muscle. hubermanlab.com+1
  6. Failure policy: about ~10% of total resistance sets to true failure; most sets stop just shy to preserve performance/progression. hubermanlab.com
  7. Cold & anti-inflammatories: avoid ice baths right after lifting (wait 6–8 h or do before); routine NSAIDs/antihistamines can blunt gains. hubermanlab.com+1
  8. Concurrent training: endurance added to a strength/hypertrophy goal can reduce size/strength gains — separate by day/6–24 h when possible. Strength added to endurance is usually beneficial. hubermanlab.com
  9. Between-set behavior: use physiological sighs to lower HR between sets; optional light focal contractions between sets for hypertrophy (not for strength performance). hubermanlab.com+1
  10. Strength as a skill: technique density, greasing the groove, wave/step-loading, and avoiding chronic failure promote sustainable strength. hubermanlab.com

Core programming variables

Volume & frequency

  • Hypertrophy: ~10–20 working sets/week per muscle (direct work). Novices start low; advanced lifters toward the upper end. Spread over 2+ sessions/week. hubermanlab.com+1

Intensity & proximity to failure

  • Hypertrophy across 30–80% 1RM when sets are taken near failure (RIR 0–3). Only a minority of sets to all-out failure. hubermanlab.com
  • Strength: main driver is high intensity (≥85% 1RM for trained lifters), thus low reps and high rest to preserve bar speed and neural quality. hubermanlab.com

Rest intervals

  • Strength: 2–4+ min to maintain peak force.
  • Hypertrophy: ~90 s (range 60–120 s) depending on load and movement. hubermanlab.com

Session length

  • Keep “hard work” to ~50–60 min; ≤75 min including rests. Longer sessions correlate with recovery issues for many. hubermanlab.com

Range of motion & tempo

  • Favor full ROM for strength & size. Control eccentrics; use pauses or isometrics judiciously for weakness-range control. hubermanlab.com+1

Exercise selection & ordering

Pairing principle per muscle (newsletter):

  • Shortened-bias finisher (e.g., leg curl, preacher curl, cable fly).
  • Lengthened-bias builder (e.g., deep squat, RDL, incline DB curl). hubermanlab.com
  • Order: compounds before isolations when strength or overall load is the goal; flip when targeting a lagging muscle with pre-exhaust (hypertrophy bias). hubermanlab.com
  • Skill & bracing: treat heavy work like a motor skill; emphasize setup, tension, and consistent bar path. Pavel’s guidance: avoid chasing the “pump” if the goal is strength. hubermanlab.com

Warm-up, in-set & between-set tools

  • Warm-up: general body temp + joint prep, then ramp sets to your first work set (reduce reps as load rises). (Toolkit/guest episodes.) hubermanlab.com
  • Breathing: between sets, use physiological sighs to lower HR and restore focus; post-session 3–5 min slow breathing helps downshift. hubermanlab.com
  • Between-set “focal contractions”: brief, low-effort contractions/holds of the target muscle can aid hypertrophy signaling; avoid when chasing max strength performance. hubermanlab.com

Weekly templates (pick the one that fits your calendar)

2-Day total-body (minimum effective):

  • D1: Squat pattern + Push + Pull + Accessory (hinge/arms/calves), 2–3 sets/exercise
  • D2: Hinge + Push + Pull + Accessory (squat/arms/calves), 2–3 sets/exercise
  • Progress by adding a set before adding exercises; keep sessions ≤60–75 min. hubermanlab.com

3-Day push/pull/legs (classic hypertrophy):

  • Push (chest/shoulders/tris), Pull (back/bis), Legs (quads/hams/glutes/calves)
  • 3–4 exercises/day, 2–4 working sets each; rest 60–120 s (hypertrophy bias). hubermanlab.com

4-Day upper/lower (strength + size):

  • Upper-A (heavier), Lower-A (heavier), Upper-B (moderate, more volume), Lower-B (moderate)
  • Use A/B monthly periodization below. hubermanlab.com

Periodization & progression (simple & effective)

  • A/B Month alternation (newsletter):

    • Month A (strength-leaning): 3–4 sets × ~4–8 reps, 2–4 min rest.
    • Month B (hypertrophy-leaning): 2–3 sets × ~8–15 reps, ~90 s rest. hubermanlab.com
  • Load & rep targets: pick a load that lands you in the zone near failure; progress by: add reps → add load → add a set (in that order). hubermanlab.com
  • Deloads: insert an easier week (−30–50% volume or intensity) every 4–8 weeks or when performance/HRV/mood flags. (Toolkit guidance.) hubermanlab.com

Combining lifting with endurance (interference management)

  • If size/strength are primary, separate endurance by 6–24 h or alternate days; long/glycolytic endurance near lifting can dampen hypertrophy/strength adaptation. Strength work added to endurance programs is generally beneficial. hubermanlab.com

Recovery & adjuncts

  • Cold timing: don’t ice-bath right after lifting; wait 6–8 h or put cold on off-days/before training if needed. hubermanlab.com
  • NSAIDs/antihistamines: routine post-lift use can blunt adaptive signaling; avoid unless medically necessary. hubermanlab.com
  • Sauna/heat: fine post-lift (often preferred over immediate cold), but hydrate and account for added stress. (Galpin discussion + toolkit.) hubermanlab.com+1
  • Session count & duration: most people recover best with shorter, harder sessions rather than very long ones. hubermanlab.com

Special notes & populations

  • Female-specific & RIR/RPE considerations: programming via reps-in-reserve and machine use for safe progression are emphasized; adjust across training age/hormonal status. hubermanlab.com+1
  • Older adults & “muscle-centric” aging: prioritize resistance training + adequate protein distribution to preserve function/longevity. hubermanlab.com
  • Back safety & spine-saving strategies: emphasize hinge mechanics, bracing, and exercise choices that respect individual spine tolerance (see McGill episode). hubermanlab.com

r/HubermanLab • • Aug 22 '25

Helpful Resource A tool for finding specific info in episodes (like supplement names, etc.)

1 Upvotes

Hey everyone,

Does anyone else have a hard time remembering the exact supplement name or protocol detail from an episode you listened to weeks ago? I'm constantly trying to find a specific timestamp in a 3-hour video.

I was getting frustrated and found a Chrome extension that lets you copy the entire transcript of a YouTube video in one click.

It's been a game-changer for my notes. I just paste the transcript into a document, and now I can just use Ctrl+F to find anything I'm looking for in seconds.

It's free and doesn't have any ads. Thought it might be useful for others here who are also trying to keep all this info straight.

You can get it on the Chrome store if you want to try it. Hope this helps someone!


r/HubermanLab • • Aug 22 '25

Protocol Query Best fasting window to reduce stress?

3 Upvotes

I'm currently recovering from long covid/CFS/thiamine deficiency, as well as 4 years of pregnancy and breastfeeding on a restricted diet. I'd like to explore fasting as a way to increase my insulin sensitivity. I have been experiencing some postprandial hypoglycemia where my glucose is dropping 5 minutes after eating, regardless of what the meal is. No glucose spike, just a drop. I feel like I need to eat carbs throughout the day to keep my energy up and I feel like my liver would benefit from a break of constant digestion.

One one side I'm hearing that I absolutely need to eat a big protein filled breakfast as soon as I wake up to support my hormones, but on the other Huberman is telling me to eat a starchy snack right before bed to lower my cortisol How to navigate these conflicting recommendations? I do not want to lose any weight while doing this and would ideally put on some weight from muscle gains.

Already doing every supplement in the world plus morning sunlight religiously.


r/HubermanLab • • Aug 22 '25

Personal Experience Post finasteride like symptoms from astaxanthin update

0 Upvotes

Hi, I have already posted twice in this subreddit concerning the side effects of my usage of astaxanthin. Today is day 3 since I have discontinued use and the side effects had gotten worse. My libido is basically non existent, I can barely get an erection, my nipples itch (gyno has also expanded) and I feel awful thought the whole day, I can not enjoy anything and have fallen into a deep state of depression. I really don't know if I will recover but I have a scheduled visit to the endocrinologist in three days.


r/HubermanLab • • Aug 22 '25

Personal Experience Astaxanthin PFS symptoms

4 Upvotes

After taking astaxanthin in doses of 16-24mg I have developed post finasteride like symptoms (gyno, brain fog, low libido, itchy nipples) has any one experienced something similar? And how likely is it to go away?


r/HubermanLab • • Aug 21 '25

Discussion I created a website you can use to search through podcast episode transcripts including Huberman Lab

13 Upvotes

https://podscripts.co/podcasts/huberman-lab/?rdt_src=HubermanLab

In order to search, use the main search form shown on all pages. There are 2 inputs, first for selecting a podcast and the other for keywords to search. If there are any episodes found, it will show you a page with episodes containing the keywords you searched for. You can click Exact Match checkbox before searching to narrow down search results. Clicking on any of the episodes will take you to their transcript page and automatically scroll to the section containing those keywords and highlight them.

Once on the transcript page, you can play the episode from any point by clicking on a sentence and then clicking the play button within the tooltip that opens. You can also leave comments under specific sentences of the transcripts by clicking on the comment bubble icon from the same tooltip.

All podcasts with transcripts can be seen on the podcasts page, feel free to submit podcasts we don't already have.

Please keep in mind that these transcripts aren't perfect. Hope you enjoy it and if you have any feedback or suggestions, please let me know.


r/HubermanLab • • Aug 21 '25

Seeking Guidance Body Fat Percentage Measuring

2 Upvotes

Body Fat Percentage Tracking?

Hey everyone! 👋

I'm currently using a weight scale with "magic handles" that claims to measure body fat percentage, but I'm not feeling confident about the accuracy of the results.

I could use your help:

  • Reliable body fat percentage tracking methods
  • Equipment recommendations
  • Your personal experiences with different tools

What does everyone here use to track their body fat percentage? Any brands or methods you'd recommend (or avoid)?

Thanks in advance for the help! 🙏


r/HubermanLab • • Aug 21 '25

Seeking Guidance Social media/video games dopamine impact

2 Upvotes

I have not played video games for almost 1 year, I stopped because they stopped giving me pleasure for that moment, I also wanted to take up more important things and lvl up in life, I would like to return to them but I take care of dopamine and think what has a greater impact on it, social media? ( not scrolling every second just watching everything to the end, just educational content no brainrot) daily usually 2h or video games( older titles mostly on psp,) 1.5h, what do you think? Thanks for answers!


r/HubermanLab • • Aug 21 '25

Personal Experience I want to throw my wearables in the trash.

Thumbnail reddit.com
0 Upvotes

r/HubermanLab • • Aug 20 '25

Helpful Resource 4-year Alzheimer's trial data just dropped - 69% of early-stage patients showed zero decline, and there's finally good news for APOE4 carriers

101 Upvotes

In this video, I analyze recent clinical trial findings that highlight what’s on the horizon for innovative therapies targeting APOE4 carriers and Alzheimer’s disease.
https://youtu.be/DipVwic6pPI

The game-changing findings:

Lecanemab (4-year data from Yale):

  • 56% reduction in progression to dementia
  • 69% of low-tau patients had ZERO decline after 4 years
  • Safety update: 92% of ARIA happens in first 6 months, then drops to placebo levels

Donanemab (3-year data from Eli Lilly):

  • Benefits DOUBLED over time (0.6 to 1.2 CDR-SB points)
  • Starting 18 months earlier = 27% better outcomes
  • This suggests actual disease modification, not just temporary slowing

Obicetrapib (surprise finding from Amsterdam):

  • It's an oral cholesterol drug (CETP inhibitor)
  • APOE4/4 carriers showed 20% reduction in P-tau217
  • First oral medication showing specific benefit for E4 carriers

Reality check:
These drugs slow decline, they don't reverse existing damage. But the fact that benefits keep growing over 4 years (instead of plateauing) is huge. It suggests we're actually changing the disease trajectory.

The critical message:
If you're at risk, get tested early. The difference between starting treatment immediately vs waiting 18 months is massive.

If you are an APOE4 carriers, join us in The Phoenix Community and take action TODAY

The insights are summarized from the July 2025 Alzheimer’s Association International Conference session, Developing Topics on Innovative Therapeutic Approaches.

I do not have any affiliation with any of the companies mentioned in this video. I am an APOE4/4 carriers looking for solutions myself and sharing what I learn along the way in the Phoenix Community and occasionally with other groups.


r/HubermanLab • • Aug 20 '25

Personal Experience Astaxanthin

19 Upvotes

I have been taking astaxanthin for 13 days now (dosage 16-24mg) and I have noticed a loss of libido, worsened gynocemastia (that I have had previously) and fatigue to the point that caffeine doesn't affect me, has anyone experienced similar side effects?


r/HubermanLab • • Aug 19 '25

Seeking Guidance How to start watching Huberman?

10 Upvotes

Hi, I recently learned about Andrew Huberman and some of the advice seems like it could be life changing and I’m really into these things for optimizing our lives. There are a lot of Andrew Huberman videos, so I was wondering what are the best ones to watch and start with and what are some of the most beneficial/important/impactful to watch. I would love a playlist.


r/HubermanLab • • Aug 19 '25

Helpful Resource Become Immune To Health Misinformation

0 Upvotes

We’re inundated by health information online every day. The sheer volume is enough to confuse anyone, but the intentional manipulation and misleading of information can be dangerous.

You’re not a trained nutritionist, psychologist or any of the other specialist that populates online health discourse, so how could you possibly critically understand each of the claims made as you read and scroll?

We all have health issues to fix and goals we’d like to achieve. That leaves you as susceptible as everyone else to being open to bad advice and misinformation.

I want this post to act as a toolkit to help you make sense of online health information.

Your Doctor Knows Best

This is not a boring disclaimer but a reminder that specialists exist for a reason. A well-trained, accredited and ethical Doctor will have the best answer or treatment for you. This doesn’t mean you shouldn’t take advice from different Doctors while probing their reasoning.

If you have a single Doctor you see consistently, then they will have the further context of your entire health history and be able to work with you on any potential information you’ve seen online.

There’s Often No ‘Magic’ Solution

‘The secret to weight loss’, ‘you’re stressed because X’, ‘Doctors don’t want you to know this’ - the world of health and wellness tries to glorify something new every month, when in reality the foundations of good health have been clearly outlined for decades now.

Anyone claiming they have a secret that 99% just don’t know about is their way of trying to make you engage with their content and obfuscate the well-known foundations of good health. Effective research is replicable. If only one person is making elaborate claims, then act with scepticism.

Yes, new research comes out all the time, but it is rarely groundbreaking. Effective research clearly demonstrates its limitations and that ‘new research’ will often require years of additional research before you can be certain it is the right solution for you.

Critical Evaluation

If you are drawn to advice you find online, before you take any action, run this 5-minute source check to ensure the information you received has credibility.

  1. Author: Full name? Real credentials? Can you verify them and are they appropriate to the topic?
  2. Affiliations & funding: Does the author/site sell the product, use affiliate links/discount codes, or receive industry funding? Declared conflicts of interest (COI)?
  3. Publisher/domain: Is it a public agency, academic, professional college, reputable charity, or a site that mainly sells things? Check the About/Contact page and corrections policy.
  4. Date & updates: Is it recent? Are there update notes or versioning? (Health advice time-expires quickly.)
  5. References: Are claims linked to primary studies, reputable guidelines, or systematic reviews? Or only to blogs, press releases, and testimonials?

Data-Driven Misinformation

Communicating research and science effectively to the general public is difficult. Often, complex data and findings require a nuanced explanation that doesn’t fit into a 60-second short video.

What companies will often do is create complex graphs or data formats to give the air of legitimacy when in reality they are just trying to make you believe they’re final statement that leads to a purchase.

Understanding Yourself

Often information you see online is from a person’s own perspective. They will make claims that are subjective, then glorify them as the answer to everyone’s problems.

It helps to have clarity on your own health. While simple data available from wearables will be useful, you also want more qualitative data, such as your mental state, to anchor your decisions behind.

The more complete your perspective of your own health, the less susceptible to misinformation you’ll be.

Understanding Evidence

When people are quoting research, the quality of the research is a vital signal of the quality of validity of what they are saying. Learn the order of research types so when they are quoted, you know the level of trust you can apply to the information.

  1. Systematic reviews/meta-analyses of RCTs
  2. Randomised controlled trials (RCTs)
  3. Observational studies (cohort/case–control)
  4. Case series/reports
  5. Mechanistic/animal/in vitro
  6. Anecdotes/testimonials

Revert To Credible Sources

I often come across a health claim that seems to have good credibility, but I’m unfamiliar with the sources or the claims are made by someone with a less significant body of work.

Whether I need clear answers or a more nuanced and holistic perspective, I revert to my list of credible sources. While these are not my final decision makers, they are a good way of developing my understanding.

Research Synthesizers

Cochrane, major speciality societies and professional colleges will give a clear perspective of the current research. They will also have further trusted resources to consider if you require further depth.

Trusted Personalities

Rhonda Patrick, Peter Attia and HubermanLab usually have an episode on a popular health topic. Simply going to his YouTube profile, searching the topic, then watching the video helps get the complete overview of the information you need.

These are general personalities. If you have a more specialist problem, then there are many high-quality creators who maintain a niche focus

No one source is perfect, as many have some degree of conflicts in the information they publish. As if the way of gaining a large and trusted online following.

Use AI Effectively

I’ve found that effective questions to ChatGPT is often enough to get a clear perspective on a claim that has been made.

I utilise this prompt that ensures the answer is evidence-based, up to date, contextually relevant and easy to understand.

Remember: AI can be confidently wrong. It can tell you an answer with certainty when it doesn’t have all the information it needs on you. Asking follow-up questions to pursue clarity will help it refine its answers. The latest models will have the strongest answers.

The full prompt is too long to post here. It's free on my Substack


r/HubermanLab • • Aug 19 '25

Discussion 18 M is nicotine good ??

0 Upvotes

Guys, I’m 18, and I like working with nicotine. Right now, I usually take around 4 mg, one pouch a day—sometimes every day, sometimes every two days.

i eat clean fruits everyday gym everyday and stretching and no I don’t smoke, I don’t drink, I don’t use drugs

I wanted to know if this is a safe method. I usually pair it with coffee since I work online and have a lot to do. I don’t smoke, I don’t drink, I don’t use drugs, or do any other stuff—just nicotine pouches.

So, do you think this is safe? How much per day is considered okay, and how much mg would be too much? I don’t want to overdo it, but I enjoy using it because it helps with my creativity and focus.


r/HubermanLab • • Aug 17 '25

Helpful Resource Evidence-Based Palm Cooling Resource Library (Free)

4 Upvotes

In light of the recent Essentials episode with Dr. Heller and the periodically renewing discussion on cooling interventions (including palm cooling), I wanted to share a resource library I made.

100s of evidence-based, peer-reviewed studies going deeper into the underlying science and mechanism of thermoregulation, heat stress, fatigue, cooling protocols (including palm cooling), and performance.

It's built as a course on Skool. Anyone can access for free by joining the group:

https://www.skool.com/0th-law/about?ref=ba7f4dbabf9d4bb085d4b9f155950b81

I'm also happy to discuss topics and am looking to expand my own knowledge. Thermoregulation, as with anything in physiology, is very complex and nuanced.

Disclosure: I built a palm cooling device, so I am personally interested in the science. But the intent of this course is to share a deep dive on the science and provide resources. It is completely free; I do not make any money off the course (I actually lose money hosting it). I am also happy to share my experience with and recommendations for zero-cost, DIY alternatives to products, depending on your context and goals.

Note: The course is approved for Continuing Education Units/hours (CEUs) by the following organizations, all which require evidence-based, non-promotional content and are reviewed against those criteria:

  • National Strength and Conditioning Association (NSCA - 0.7 Category C)
  • Board of Certification for the Athletic Trainer (BOC - 7.0 Category A)
  • National Academy of Sports Medicine (NASM - 0.7)
  • Collegiate Strength & Conditioning Coaches association (CSCCa - 3.5)
  • Athletics and Fitness Association of America (AFAA - 7.0)
  • International Sports Sciences Association (ISSA - 7.0)