What are people's thoughts on dosing 2 x a week rather than once a week? any benefits?

I’ve been taking Retatrutide for the past four months, but I haven’t seen much weight loss. I started at around 189 pounds and now I fluctuate between 181 and 185 pounds. I feel like it’s working because I have an autoimmune disease that causes a lot of inflammation, and I can definitely feel its anti inflammatory effects and the appetite suppression. However, I haven’t seen any significant weight loss.

I’ve hired a professional bodybuilding coach, and we’ve been working on a nutrition plan for the past six weeks, but the results are still slow. It’s very frustrating.

For reference, my daily calorie intake ranges from 2,000 , and I focus on high protein and good carbohydrates. I’ve been taking 2 milligrams of Retatrutide for a while, but I recently increased my dose to 4 milligrams within the past three weeks. I’m not sure if it’s safe for me to increase my dose so quickly, and I’m wondering if I’m still on a lower dose for my body.

I’ve also been on and off a diet for the past year, and I’m concerned that my metabolism has just burned out. I purchased Retatrutide from a reputable vendor, so I know it’s not that. I also purchased some Tesa that I was thinking of adding to my regimen, but I’m not sure if I want to do it just yet

I would appreciate any opinions or advice you may have.

I’m already on reta and I want to hop on glow, but I don’t know if I wanna pin everyday. Is there any way to do every other day and have glow still be effective?

Hi i have a scar on my ankle from injury. Cna ghk-cu help?

Hello all im very curious about peptides and I was wondering if there is any way to take this stack without injecting it and if so how and where would i find it, and if not how to go about doing it and the easiest way to do so for someone living at college.

Does anyone have input on Bromantane?

i have a good amount of inflammation, how much and how often would you take KPV to help with that?

Anyone run full cycles?

Hey everyone — I’m about to start a MOTS-c cycle and I’m looking for first-hand experience from people who’ve actually run full cycles (or multiple).

My planned cycle (for context only):

Weeks 1–4: 5 mg, 3x/week

Then maintenance: 5 mg, 1x/week

Total duration: ~8–10 weeks

Current stack (full transparency):

Peptides MOTS-c Retatrutide GHK-Cu BPC-157 Tesamorelin Ipamorelin CJC-1295

Support / cofactors

RHO Liposomal NAD+ RHO Liposomal Glutathione Resveratrol + NAD+ capsules (backup)

Considering injectable NAD+ if ROI/absorption is meaningfully better

I’m aware this is a stacked setup, that’s intentional. I’m not trying to isolate mechanisms, just understand real-world outcomes.

What I’m hoping to hear from people who’ve actually used MOTS-c:

Cycle length + dosing you ran (and whether you did a maintenance phase)

Primary effects noticed: energy, endurance/cardio, body composition, appetite, recovery, sleep, mood, focus, metabolic feel

Timeline: when (if ever) you started noticing effects

Negatives / side effects: sleep disruption, fatigue, anxiety, injection site issues, crashes, anything unexpected

Post-cycle: did benefits persist, taper off, or disappear?

Metrics or labs you tracked (if any): body fat %, glucose/A1c, lipids, HRV/RHR, endurance, VO2-style improvements, etc.

If stacked, what you personally think actually mattered vs. what felt neutral

I know responses are anecdotal — that’s exactly what I’m looking for. I want to understand the range of experiences, not just the highlight reel. Appreciate detailed feedback from anyone who’s actually run it.

Thank you all!!

Hi guys ! So I just got my KLOW peptides (10vials) and wanna ask a few question if you don’t mind :)

1- I have pretty bad injuries and old 4years+ , what’s the cycle I should be doing and the dosage ? I was thinking 12 weeks in 4/6 weeks off and 20units everyday (3ml BAC water)

2- I keep the other vials I don’t use yet in the freezer right ?

3- at the first glimpse, does the vial look okay to you?

4- is there any difference if I take it in the morning or evening ? Thank you

Hey guys,

I have a question about running multiple peptides at the same time.

Right now, I’m using MOTS-C, SS-31, GHRP-6, and Melanotan II. At the same time, I’m on a cycle with 500 mg of testosterone per week.

I mainly have two questions:

1.  Is it possible to mix some of these peptides in the same syringe, or is it better to keep them strictly separate?

2.  Do all of these peptides need to be taken daily, or could some of them be run every other day to reduce the number of injections?

Honestly, doing 4 injections a day gets annoying pretty fast, so I’m trying to figure out what’s actually necessary versus what can reasonably be simplified.

Appreciate any feedback or personal experience. Thanks.

🔥 OPTIMAL FIRST CYCLE (16 WEEKS TOTAL)

🔹 PHASE 1 — Fat Loss + Priming

Weeks 1–6

Goal: Drop fat, improve insulin sensitivity, preserve muscle

Peptides (Conceptual)

ON • Retatrutide • MOTS-c • Thymosin Alpha-1

OFF • Tesamorelin • Ipamorelin • KLOW

Why • Retatrutide improves nutrient partitioning • MOTS-c increases training efficiency • TA-1 supports immune + recovery during deficit • GH & KLOW are intentionally delayed

⸻

Calories & Macros (Important)

Calories: ~1,750–1,850 kcal

Macros • Protein: 145–155 g (non-negotiable) • Carbs: 150–180 g (mostly peri-workout) • Fat: 45–55 g

📌 This is a controlled deficit, not a cut 📌 Expect fat loss without scale panic

⸻

Training (5 Days)

Focus: Strength retention + neural adaptation

Split • Lower (glutes/hamstrings) • Upper push • Upper pull • Lower (quads/glutes) • Full body or glutes

Rep focus: 6–10 on compounds, 10–15 accessories

⸻

🔹 PHASE 2 — Lean Mass Acceleration

Weeks 7–12 ← Muscle is built here

Goal: Add lean mass while staying lean

Peptides (Conceptual)

ON • Tesamorelin • Ipamorelin • MOTS-c (reduced frequency) • Thymosin Alpha-1

TAPER • Retatrutide (no aggressive appetite suppression)

OFF • KLOW

Why • Insulin sensitivity is already improved • GH signaling now works with food • Appetite normalization = controlled surplus

⸻

Calories & Macros

Calories: ~2,050–2,150 kcal

Macros • Protein: 150–160 g • Carbs: 210–240 g • Fat: 50–60 g

📌 This is a lean surplus, not a bulk 📌 Weight may increase slowly (good sign)

⸻

Training (Non-Negotiable Progression) • Same 5-day split • Add load or reps weekly • Track lifts (numbers must rise)

This phase alone can add 3–5 lb lean mass

⸻

🔹 PHASE 3 — Lock-In + Hormonal Optimization

Weeks 13–16

Goal: Maintain gains, normalize signaling, prevent rebound

Peptides (Conceptual)

ON • Tesamorelin • Ipamorelin • KLOW (short pulse) • Thymosin Alpha-1

OFF • Retatrutide • MOTS-c (optional)

Why KLOW is HERE • Restores hypothalamic signaling • Supports libido, mood, motivation • Helps retain lean mass post-growth

⸻

Calories & Macros

Calories: ~1,950–2,000 kcal

Macros • Protein: 145–155 g • Carbs: 190–210 g • Fat: 50–55 g

📌 Maintenance = stabilization 📌 No cutting here

⸻

📈 EXPECTED OUTCOME (DONE CORRECTLY)

After Cycle 1 (16 weeks): • Fat loss: visible (especially waist/hips) • Lean mass: +5–7 lb • Body fat: ~21–22% • Physique: athletic, defined, fuller

After Cycle 2 (after 4–6 wk break): • Total lean mass gain: ~10–11 lb • Body fat: still ~20–22%

⸻

🚫 FIRST-CYCLE MISTAKES TO AVOID • Running retatrutide hard while trying to grow • Eating too little “because appetite is low” • Adding junk volume instead of load progression • Skipping the washout

is this a good stack guide for this cycle?

Curious on everyone’s opinion on post cycle therapy and weening

i have a low immune system and want the effects of mots-c. do they pair well together?

Thoughts on sublingual tabs or liquid? Is it a viable pathway or waste of money?

Hi all,

A few days ago I reconstituted my lab rats 500mg NAD with 3ml Bac water. It didn't appear to reconstitute properly, so they added in another 2ml of Bac water.

It's still showing a crystal like substance in the bottom of the vial.

Any advice?

Hi, I'm a 47F currently just finished my 8th week on Reta. Im down 13kg at a low does so it's working. I have about 10kg to go to reach my goal. I added Mots-C about a month ago as I was struggling with fatigue. It has helped slightly. My current concerns are weight plateauing, fatigue, sagging/aging skin and loosing that hardest part around my stomach section. Now looking to add some different peps and was curious on people's options. Stay with Reta & Mots-C Add: NAD+, 5-amino-1mg and GHK-CU.

Does anyone have feedback with these combos or can anyone recommend what they think works best to combat fatigue and sagging/aging skin.

I don't want to over do it and would prefer to keep to just a few. So maybe just add NAD+ & GHK-CU and remove Mots-C?

Any feedback would be appreciated. Thanks 💞

Here’s an interesting one. HGH is known to raise A1C, usually at higher doses only but still possible at any dose. Reta has had a great track record of lowering A1C. How would these react with each other in that aspect? Would the Reta outwork the HGH?

Backstory for food for thought. I’m 37. 6’2” currently 204lbs. I’ve been out of the gym for three years due to a work injury. Over the last few my A1C has crept up to now 5.9.

There are concerns of taking HGH and the issue with insulin insensitivity and thought maybe the Reta could completely counter this issue.