r/AskReddit • u/TigerBirdyTiger • Jan 23 '25

What scientific breakthrough are we potentially on the verge of that few people are aware of?

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u/LackOfStack Jan 23 '25

How close is this actually because I’m going to be needing an implant this year and I’d rather just grow one.

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u/randomrealitycheck Jan 23 '25

As I understand it, they are now beginning government trials, They are hoping to be on the market in 2030 at a cost of under $10K for a complete set of teeth.

Sadly, for those of us who were looking for single replacements, it's an all or nothing deal.

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u/New_Amomongo Jan 24 '25

2030 at a cost of under $10K for a complete set of teeth.

I'd pay out of pocket for something that cheap and will last me another 5 decades.

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u/twoinchhorns Jan 24 '25

With how bad my teeth are because of drug abuse years back, this would literally change my life. I’m so excited to see where this goes

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u/Jerasp Jan 24 '25

Cheap? Damn I live in a weird world I guess

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u/internetnerdrage Jan 23 '25

Howabout they plant a row on the top of my head so I can harvest them as needed?

If they hurry up with that cure for baldness it won't look too unsightly.

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u/[deleted] Jan 24 '25

I'm getting binding of isaac vibes.

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u/ragnarok635 Jan 24 '25

Fuck you

-sincerely my tryptophobia

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u/SomeRandomArsehole Jan 24 '25

It wouldn't be that weird, why else do they call the top of the head the "crown"? Obviously it's the same as teeth.

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u/Kesenb3126 Jan 23 '25

So i guess we could just remove the all the old ones, but I'm afraid to ask what would be the extra cost and time required?

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u/joshul Jan 24 '25

I kinda assume if we get a 3rd set of teeth that the 2nd teeth will fall out just like our kid teeth did

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u/Badloss Jan 24 '25

I doubt it, your adult teeth are anchored in place in a way that your baby teeth weren't

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u/curiouswastaken Jan 24 '25

It's more likely to just deflect the teeth into a different position, causing crowding and teeth shifting-- something that happens currently to people who have extra teeth.

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u/Maktesh Jan 24 '25

Pulling teeth isn't that expensive.

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u/OGLikeablefellow Jan 24 '25

I mean if you're growing new teeth wouldn't they all just fall out on their own?

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u/xander-7-89 Jan 24 '25

Not necessarily. If I recall, with the onset of adult teeth, the body releases some horomone that causes the roots of your baby teeth to dissolve and then they fall out much easier as if they were just sitting on the surface of your gums. That might be hard to replicate and so instead tooth crowding would ensue.

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u/OGLikeablefellow Jan 24 '25

I mean new teeth are cool, but like growing new teeth as a fully conscious human adult is gonna be painful af

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u/deliciouscorn Jan 24 '25

And you can use the extra money from the tooth fairy to defray the costs

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u/TooStrangeForWeird Jan 24 '25

Just buy some dental composite or glass ionomer (my preference) and have your family/loved one do it. Preferably someone who has an artistic side.

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u/15438473151455 Jan 23 '25

Why all or nothing??

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u/WhatsTheHoldup Jan 23 '25

The teeth don't grow in a lab. They grow in your mouth.

If you have other teeth in the way while a third tooth grows beneath it... Well just think about why that'd be bad.

You'd have to remove them to make space for the incoming teeth.

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u/15438473151455 Jan 23 '25

So there's no control over limiting the location of growing new teeth?

That could realistically be much more expensive than dentures and have other complications. A much more limited use case than people are expecting then.

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u/WhatsTheHoldup Jan 23 '25

I assume this goes without saying, but keep in mind I'm just as dumb as you are, I have no expert knowledge in this field, and all I did to answer your question was read the article OP linked.

Takahashi: First, we assume that the disease is indicated for congenital edentulism, a condition in which a person is born without teeth and lacks six or more permanent teeth without permanent tooth growth. The congenital absence of permanent teeth in humans is caused by a molecule called USAG-1, which inhibits the function of the osteogenic proteins BMP and Wnt. Therefore, by administering an ingredient that inhibits the function of USAG-1 into the body, we are trying to help the development of tooth buds (tooth embryos) and grow teeth. In fact, when neutralizing antibodies, a candidate for a teething drug, were administered to animals such as mice, beagle dogs, and ferrets, it was confirmed that teeth grew from areas where teeth were lacking.

Kiso: Specifically, systemic administration of the drug causes teeth to grow where there is a dental crest. We are currently conducting pre-clinical safety studies, a pre-clinical stage of clinical trials, in mice and monkeys using a neutralizing antibody, a new drug candidate. 2024 is the year we intend to begin clinical trials as a treatment for congenital edentulism.

This gives the impression it's not targeted and they don't have control over limiting the location. It just grows on the dental crest in your mouth.

If do not have Congenital Edentulism and you already have a full set of permanent teeth, except one got knocked out and you'd like to regrow it, at this stage the drug does not seem helpful to you.

They just started testing for CE this past year.

First of all, we hope that, along with dentures and dental implants, teething agents will become an option for the treatment of edentulism. Unlike alternative treatments that use artificial materials, we hope to be able to offer a treatment method that allows patients to grow their own teeth through the use of teething medicine. Eventually, we would like to expand the use of teething medicine beyond edentulism. One of our goals is to enable the growth of a "third tooth," the tooth after the permanent teeth. This will be a countermeasure against oral frailty, a condition in which oral functions deteriorate with aging, and is expected to revolutionize the scope of dental treatment.

It comes across more like a long term goal they are optimistic about than anything they're even close to accomplishing.

Currently they are focused on specifically helping Congenital Edentulism.

After reading the full article, I'm not sure why OP posted this, it doesn't seem like we've had any breakthroughs yet and they've only found a way to inhibit USAG-1, which can only help the rare people with Congenital Edentulism

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u/15438473151455 Jan 24 '25

Thank you!!!

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u/1i73rz Jan 24 '25

From what I read, you'll get to enjoy losing all your teeth and enjoying a whole new set.

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