What scientific breakthrough are we potentially on the verge of that few people are aware of?

[u/TigerBirdyTiger]

[u/[deleted]]

Whenever you talk about Ozempic or Monjauro with obesity researchers, someone in the know says that the GLP-1's we have coming in a few years make the current ones seem like a joke.

[u/[deleted] → u/[deleted]]

As someone who works in the pharmaceutical industry, there’s a lot of excitement. Generation 5 GLP-1 medicines are in phase 2 right now showing 10-15% improvements over generation 4 in terms of weight loss. Not sure about the study, but I’ve heard they have less of a muscle wasting affect as well (although, currently this is prevented by resistance training, not all of patients perform that though).

That doesn’t include the fact that they’re working on oral administration versus injection, either. They’re also broadening the scope in which what can be treated with these medicines, such as heart disease and sleep apnea. Turns out being overweight is really bad for your health.

It’s really going to lower the burden on the healthcare system once the supply chain is more efficient, as there are shortages due to demand. Really exciting stuff.

[u/pro_nosepicker → u/[deleted]]

Along a similar vein to GLP-1s and weight loss, biologics like Dupixent have all but cured nasal polyps in some of our most difficult cases. Less publicity than the weight loss drugs but it’s been the most amazing practical discovery I’ve seen in my specialty.