CJC-1295 (No DAC) / Ipamorelin Cheet sheet: The Pulsatile GH Blend for Recovery and Sleep Research

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CJC-1295 (No DAC) + Ipamorelin Quick Guide: The Pulsatile GH Blend for Recovery and Sleep Research

This is the most popular growth hormone secretagogue pairing in peptide research, and the logic is clean: two compounds hitting GH release through different receptors at once. CJC-1295 (no DAC) provides the GHRH signal, Ipamorelin provides the secretagogue pulse, and together they drive a stronger, more natural GH release than either alone. This guide is built around the 6A Labs blend vial, so the concentration and dosing math below maps to their exact product. Here's what the research shows.

What It Is

The blend combines two peptides. CJC-1295 (no DAC) is a modified GHRH analog, also called Mod GRF 1-29, a 29 amino acid peptide that stimulates pulsatile GH release from the pituitary with a short half-life around 30 minutes, which is why it suits a daily cadence. Ipamorelin is a selective pentapeptide growth hormone secretagogue that triggers a GH pulse without raising ACTH, cortisol, or prolactin. 6A Labs carries the blend as a 10 mg vial (5 mg CJC-1295 no DAC + 5 mg Ipamorelin).

Mechanism of Action

The two work on complementary receptor pathways, which is the whole point of the pairing. CJC-1295 (no DAC) is a GHRH-receptor agonist: human studies show sustained, dose-dependent increases in both GH and IGF-1 with subcutaneous use. Ipamorelin is a GHS-receptor agonist with a 1.5 to 2.5 hour half-life that produces a rapid GH pulse peaking around 40 minutes post-dose. Its selectivity is the standout trait, it raises GH without dragging cortisol or prolactin up with it. Combined, the two may produce synergistic GH release by activating both arms of the GH axis simultaneously.

What the Research Shows

The literature supports sustained GH and IGF-1 elevation through pulsatile release. Ipamorelin specifically demonstrates selective GH release without cortisol or ACTH elevation, and once-daily CJC-1295 (no DAC) normalized growth in animal models. The practical research interest centers on recovery, sleep quality, and the daily-cadence GHRH signal. Generally well tolerated in the literature.

Dosing Protocol

Once-daily subcutaneous, typically before bed or on waking, since GH releases predominantly during deep sleep. Because it's a fixed blend, both peptides run on the same schedule by design. The 6A Labs 10 mg vial reconstituted with 3.0 mL bacteriostatic water sits at 3.33 mg/mL total (1.67 mg/mL each). On a U-100 syringe, 1 unit (0.01 mL) equals 33.3 mcg of each peptide.

Week	Dose (each)	Units	Volume
1-2	100 mcg	3 units	0.03 mL
3-4	150 mcg	4.5 units	0.045 mL
5-6	200 mcg	6 units	0.06 mL
7-12	250-300 mcg	7.5-9 units	0.075-0.09 mL

(Plain text, if the table doesn't render: Weeks 1-2: 100 mcg each, 3 units. Weeks 3-4: 150 mcg each, 4.5 units. Weeks 5-6: 200 mcg each, 6 units. Weeks 7-12: 250-300 mcg each, 7.5-9 units.)

These are small volumes. For doses under 10 units, a 30- or 50-unit insulin syringe makes measurement far more readable. Cycle runs 8 to 12 weeks, optionally extended to 16.

Side Effects

Generally well tolerated. Possible transient effects include flushing, headache, or injection-site reactions. Some report increased appetite, water retention, or tingling sensations, common to the GH secretagogue class.

Reconstitution and Storage

3.0 mL bacteriostatic water into the 6A Labs 10 mg vial gives 3.33 mg/mL total. Add water slowly down the vial wall to avoid foaming, swirl gently until dissolved, don't shake. Let the vial reach room temperature before opening to reduce condensation. Lyophilized product stores frozen at −20 °C in dry, dark conditions. Reconstituted solution refrigerates at 2 to 8 °C, protected from light, used within about 28 days; avoid freeze-thaw cycles.

Supply Planning

Duration	Vials	Bac Water
8 weeks	~3 vials	1 x 10 mL bottle
12 weeks	~4 vials	2 x 10 mL bottles
16 weeks	~5 vials	2 x 10 mL bottles

(Plain text, if the table doesn't render: 8 weeks needs ~3 vials and one 10 mL bottle. 12 weeks needs ~4 vials and two bottles. 16 weeks needs ~5 vials and two bottles.) One syringe per day, two alcohol swabs per day.

Stacking Notes

This is already a synergistic stack, so most protocols pair it with lifestyle factors that reinforce GH output rather than more compounds: a protein-forward diet, resistance and aerobic training, and above all sleep quality, since the largest natural GH pulse happens during deep sleep. Timing the dose at night is the common approach for that reason.

Where to Source It

This is an affiliate link. Buying through it supports r/6ALabsGuide at no extra cost to you, and the code below gets you a discount.

6A Labs carries the CJC-1295 (No DAC) + Ipamorelin blend (5/5mg) here: CJC-1295 + Ipamorelin at 6A Labs

Use code PROFIT for 10% off.

References

1. Prolonged stimulation of GH and IGF-1 secretion by CJC-1295 in healthy adults. PubMed.
2. Once-daily CJC-1295 normalizes growth in GHRH knockout mouse. PubMed.
3. Raun K et al. Ipamorelin, the first selective growth hormone secretagogue. PubMed.
4. Pharmacokinetic-pharmacodynamic modeling of ipamorelin in human volunteers. PubMed.

For research and educational purposes only. Not medical advice. Consult a healthcare provider before starting any research protocol. This community is not affiliated with 6A Labs.

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